International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Autoimmun Rev. 2022 Oct;21(10):103166. doi: 10.1016/j.autrev.2022.103166. Epub 2022 Aug 4.
While autoimmunity is a branch of medicine linked to every single organ system via direct and indirect pathways, meeting in person to discuss autoimmunity during the 13 international congress on autoimmunity (AUTO13) with participants from all over the world had a very good reason. The mechanisms involved in autoimmune diseases are of extreme importance and in fact critical in understanding the course of diseases as well as selecting proper therapies. COVID-19 has served as a great example of how autoimmunity is deeply involved in the disease and directly correlated to severity, morbidity, and mortality. For instance, initially the term cytokine storm dominated, then COVID-19 was addressed as the new member of the hyperferritinemic syndrome, and also the use of immunosuppressants in patients with COVID-19 throughout the pandemic, all shed light on the fundamental role of autoimmunity. Unsurprisingly, SARS-CoV-2 was called the "autoimmune virus" during AUTO13. Subsequently, the correlation between autoimmunity and COVID-19 vaccines and post-COVID, all were discussed from different autoimmune aspects during the congress. In addition, updates on the mechanisms of diseases, autoantibodies, novel diagnostics and therapies in regard to autoimmune diseases such as antiphospholipid syndrome, systemic lupus erythematosus, systemic sclerosis and others, were discussed in dedicated sessions. Due to the magnificence of the topics discussed, we aimed to bring in our article hereby, the pearls of AUTO13 in terms of updates, new aspects of autoimmunity, and interesting findings. While more than 500 abstract were presented, concluding all the topics was not in reach, hence major findings were summarized.
虽然自身免疫是一门医学分支，通过直接和间接途径与每个器官系统都有关联，但在第 13 届国际自身免疫大会（AUTO13）上，来自世界各地的与会者亲自讨论自身免疫问题，这是有充分理由的。自身免疫性疾病涉及的机制极为重要，事实上对于理解疾病的过程以及选择适当的治疗方法至关重要。COVID-19 就是一个很好的例子，说明自身免疫是如何深深卷入疾病之中的，与严重程度、发病率和死亡率直接相关。例如，最初术语“细胞因子风暴”占据主导地位，随后 COVID-19 被视为新的高铁蛋白血症综合征成员，以及在整个大流行期间 COVID-19 患者使用免疫抑制剂，都揭示了自身免疫的基本作用。毫不奇怪，在 AUTO13 期间，SARS-CoV-2 被称为“自身免疫病毒”。随后，自身免疫与 COVID-19 疫苗以及 COVID-后之间的相关性，都在大会期间从不同的自身免疫角度进行了讨论。此外，还讨论了关于自身免疫疾病（如抗磷脂综合征、系统性红斑狼疮、系统性硬皮病等）的疾病机制、自身抗体、新型诊断和治疗方面的更新，以及专门的会议。由于讨论的主题非常广泛，我们旨在在本文中介绍 AUTO13 的亮点，包括更新内容、自身免疫的新方面和有趣的发现。虽然有 500 多个摘要进行了介绍，但不可能涵盖所有主题，因此仅对主要发现进行了总结。
