Mahroum Naim, Hejly Ashraf, Tiosano Shmuel, Gendelman Omer, Comaneshter Doron, Cohen Arnon D, Amital Howard
Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100, Israel.
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Immunol Res. 2017 Apr;65(2):477-481. doi: 10.1007/s12026-016-8886-7.
The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database. The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age- and sex-matched controls regarding the proportion chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel. There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46-2.90). To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls.
病毒感染与自身免疫性疾病之间的关联在医学领域已是既定现象。已知丙型肝炎病毒感染存在这种关联；然而，在一项源自大型国家数据库的实际研究中，尚未对其与系统性红斑狼疮的关联进行研究。本研究的目的是调查系统性红斑狼疮（SLE）与慢性丙型肝炎病毒感染之间的关联。将SLE患者与年龄和性别匹配的对照组在慢性丙型肝炎病毒感染比例方面进行比较。卡方检验和t检验用于单因素分析，逻辑回归模型用于多因素分析。该研究利用以色列克拉利特医疗服务机构的医学数据库进行。与对照组相比，SLE患者中丙型肝炎病毒感染比例显著更高（分别为1.06%和0.39%；p < 0.001）。在社会经济地位较高的患者中也观察到显著关联。在多因素逻辑回归分析中，SLE与丙型肝炎病毒感染显著相关（比值比 = 2.07，95%置信区间 = 1.46 - 2.90）。总之，SLE患者的慢性丙型肝炎病毒感染比例高于匹配的对照组。
