对圭亚那紫荆内生真菌提取物抗菌活性的生物勘探。
Bioprospecting of antimicrobial activity of extracts of endophytic fungi from Bauhinia guianensis.
作者信息
Pinheiro Eduardo A A, Pina Jeferson R S, Feitosa André O, Carvalho Josiwander M, Borges Fábio C, Marinho Patrícia S B, Marinho Andrey M R
机构信息
Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
Universidade Federal do Pará, Instituto de Ciências Exatas e Naturais - Programa de Pós-graduação em Química, Rua Augusto Corrêa, 01 - Guamá, 66075-110 Belém, Pará, Brazil.
出版信息
Rev Argent Microbiol. 2017 Jan-Mar;49(1):3-6. doi: 10.1016/j.ram.2016.08.005. Epub 2017 Jan 13.
Antibiotic resistance results in higher medical costs, prolonged hospital stays and increased mortality and is rising to dangerously high levels in all parts of the world. Therefore, this study aims to search for new antimicrobial agents through bioprospecting of extracts of endophytic fungi from Bauhinia guianensis, a typical Amazonian plant used in combating infections. Seventeen (17) fungi were isolated and as result the methanolic extract of the fungus Exserohilum rostratum showed good activity against the bacteria tested. The polyketide monocerin was isolated by the chromatographic technique, identified by NMR and MS, showing broad antimicrobial spectrum.
抗生素耐药性导致医疗成本增加、住院时间延长和死亡率上升，且在世界所有地区都正上升到危险的高水平。因此，本研究旨在通过对圭亚那羊蹄甲（一种用于对抗感染的典型亚马逊植物）内生真菌提取物进行生物勘探来寻找新的抗菌剂。分离出了17种真菌，结果显示，真菌喙突埃里希霉的甲醇提取物对所测试的细菌具有良好活性。通过色谱技术分离出聚酮化合物单孢菌素，经核磁共振（NMR）和质谱（MS）鉴定，显示出广谱抗菌活性。
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