Ooi Theng Choon, Chan Kok Meng, Sharif Razinah
a Biomedical Science Programme , School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.
b Environmental Health and Industrial Safety Programme , School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia , Kuala Lumpur , Malaysia.
Nutr Cancer. 2017 Feb-Mar;69(2):201-210. doi: 10.1080/01635581.2017.1265132. Epub 2017 Jan 17.
Cancer is one of the major causes of death worldwide, and the incidence and mortality rates of cancer are expected to rise tremendously in the near future. Despite a better understanding of cancer biology and advancement in cancer management, current strategies in cancer treatment remain costly and ineffective. Hence, instead of putting more efforts to search for new cancer cures, attention has now been shifted to the development of cancer chemopreventive agents as a preventive measure for cancer formation. It is well known that neoplastic transformation of cells is multifactorial, and the occurrence of oxidative stress, chronic inflammation, and genomic instability events has been implicated in the carcinogenesis of cells. Zinc l-carnosine (ZnC), which is clinically used as gastric ulcer treatment in Japan, has been suggested to have the potential in preventing cancer development. Multiple studies have revealed that ZnC possesses potent antioxidant, anti-inflammatory, and genomic stability enhancement effects. Thus, this review provides some mechanistic insight into the antioxidant, anti-inflammatory, and genomic stability enhancement effects of ZnC in relevance to its chemopreventive potential.
癌症是全球主要死因之一，预计在不久的将来癌症的发病率和死亡率将大幅上升。尽管对癌症生物学有了更好的理解，癌症管理也取得了进展，但目前的癌症治疗策略仍然成本高昂且效果不佳。因此，现在人们的注意力已从更多地致力于寻找新的癌症治疗方法，转向开发癌症化学预防剂作为预防癌症形成的措施。众所周知，细胞的肿瘤转化是多因素的，氧化应激、慢性炎症和基因组不稳定事件的发生与细胞癌变有关。L-肌肽锌（ZnC）在日本临床上用于治疗胃溃疡，有人认为它具有预防癌症发展的潜力。多项研究表明，ZnC具有强大的抗氧化、抗炎和增强基因组稳定性的作用。因此，本综述提供了一些关于ZnC的抗氧化、抗炎和增强基因组稳定性作用与其化学预防潜力相关的机制见解。
