McCarthy Matthew William, Aguilar-Zapata Daniel, Petraitis Vidmantas, Walsh Thomas J
a Hospital Medicine , Joan and Sanford I Weill Medical College of Cornell University Ringgold standard institution , New York , NY , USA.
b Transplantation-Oncology Infectious Diseases Program , Weill Cornell Medical Center of Cornell University , New York , NY , USA.
Expert Rev Respir Med. 2017 Mar;11(3):229-238. doi: 10.1080/17476348.2017.1283986. Epub 2017 Jan 27.
Sinopulmonary aspergillosis represents a diverse collection of allergic, invasive, and chronic sinus and respiratory conditions. These diseases can affect patients with and without immune impairment and in some cases may be life-threatening. Areas covered: We review the diagnosis, classification, and therapeutic options available to treat sinopulmonary aspergillosis and look ahead to emerging diagnostic and therapeutic options that may soon play an important role in clinical practice. Expert commentary: Histopathology and tissue culture remain the gold standard for the diagnosis of invasive sinopulmonary aspergillosis, but several new molecular detection methods have recently emerged, including various PCR-based platforms, MALDI-TOF, and lateral flow assays. We examine these methodologies as well as the barriers associated with the standardization, validation, and implementation. We also explore the pipeline of antifungal agents in development to treat sinopulmonary aspergillosis.
鼻窦肺曲霉菌病涵盖了多种过敏性、侵袭性以及慢性鼻窦和呼吸道疾病。这些疾病可影响免疫功能正常和受损的患者，在某些情况下可能危及生命。涵盖领域：我们回顾了用于治疗鼻窦肺曲霉菌病的诊断、分类及治疗选择，并展望了可能很快在临床实践中发挥重要作用的新兴诊断和治疗方法。专家评论：组织病理学和组织培养仍是侵袭性鼻窦肺曲霉菌病诊断的金标准，但最近出现了几种新的分子检测方法，包括各种基于PCR的平台、基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）和侧向流动分析。我们研究了这些方法以及与标准化、验证和实施相关的障碍。我们还探讨了正在研发的用于治疗鼻窦肺曲霉菌病的抗真菌药物管线。
