自噬与自身免疫
Autophagy and autoimmunity.
作者信息
Wu Dennis J, Adamopoulos Iannis E
机构信息
Graduate Group in Immunology, University of California at Davis, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA.
Graduate Group in Immunology, University of California at Davis, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USA; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, USA.
出版信息
Clin Immunol. 2017 Mar;176:55-62. doi: 10.1016/j.clim.2017.01.007. Epub 2017 Jan 15.
Autophagy is a highly conserved protein degradation pathway from yeasts to humans that is essential for removing protein aggregates and misfolded proteins in healthy cells. Recently, autophagy-related genes polymorphisms have been implicated in several autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and multiple sclerosis. Numerous studies reveal autophagy and autophagy-related proteins also participate in immune regulation. Conditional deletions of autophagy-related proteins in mice have rendered protection from experimental autoimmune encephalomyelitis, and TNF-mediated joint destruction in animal models of multiple sclerosis and experimental arthritis respectively. As autophagy is strongly implicated in immune functions such as removal of intracellular bacteria, inflammatory cytokine secretion, antigen presentation, and lymphocyte development, in this review we summarized current understanding of the roles of autophagy and autophagy proteins in autoimmune diseases.
自噬是一种从酵母到人类高度保守的蛋白质降解途径，对于清除健康细胞中的蛋白质聚集体和错误折叠的蛋白质至关重要。最近，自噬相关基因多态性与包括系统性红斑狼疮、类风湿性关节炎、银屑病和多发性硬化症在内的几种自身免疫性疾病有关。大量研究表明，自噬和自噬相关蛋白也参与免疫调节。在小鼠中条件性缺失自噬相关蛋白分别使其免受实验性自身免疫性脑脊髓炎以及多发性硬化症和实验性关节炎动物模型中肿瘤坏死因子介导的关节破坏。由于自噬与诸如清除细胞内细菌、炎性细胞因子分泌、抗原呈递和淋巴细胞发育等免疫功能密切相关，在本综述中，我们总结了目前对自噬和自噬蛋白在自身免疫性疾病中作用的认识。
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