Department of Maxillofacial Surgery, Medical University of Silesia, Sosnowiec, Poland.
Burn Wound Unit, Burn Center, Siemianowice Slaskie, Poland.
Biomed Res Int. 2016;2016:7649206. doi: 10.1155/2016/7649206. Epub 2016 Dec 20.
This article reports the influence of an autologous leukocyte- and platelet-rich plasma (L-PRP) injection as a minimally invasive method on supporting wound healing processes after a mandibular odontogenic cystectomy and double mandibular fracture fixation. 113 patients were enrolled into a control group (received no L-PRP injection) and 102 patients were enrolled into an L-PRP group with an oral mucosa incision. 18 patients after a double mandibular fracture were operated on using 2 external submandibular approaches receiving no fluids in the right site (a control group) and an L-PRP injection in the left incision (L-PRP group). Clinical observations showed that the oral mucosa healed faster in patients treated with L-PRP, in comparison to cases where inductive biomaterial was not added. Pain at the L-PRP injection site was relieved within few hours after an operation in patients with double mandibular fractures. However, there were no differences observed in the progression of the healing process. L-PRP possesses inductive properties that could stimulate healing processes and it seems to be one of the most promising methods in the future for the treatment of soft tissue defects.
本文报告了自体富白细胞血小板血浆（L-PRP）注射作为一种微创方法，对支持下颌牙源性囊肿切除和双侧下颌骨骨折固定后伤口愈合过程的影响。113 名患者被纳入对照组（未接受 L-PRP 注射），102 名患者被纳入 L-PRP 组，行口腔黏膜切口。18 例双侧下颌骨骨折患者采用 2 种下颌外切开术，右侧不给予任何液体（对照组），左侧给予 L-PRP 注射（L-PRP 组）。临床观察显示，与未添加诱导生物材料的病例相比，接受 L-PRP 治疗的患者口腔黏膜愈合更快。双侧下颌骨骨折患者术后数小时内，L-PRP 注射部位的疼痛得到缓解。然而，愈合过程的进展没有差异。L-PRP 具有诱导愈合过程的特性，它似乎是未来治疗软组织缺损最有前途的方法之一。
