Das Soumyashree, Red-Horse Kristy
Department of Biology, Stanford University, Stanford, California.
Dev Dyn. 2017 Apr;246(4):328-335. doi: 10.1002/dvdy.24486. Epub 2017 Feb 24.
Knowledge on cellular differentiation pathways is critical to understanding organ development, homeostasis, and disease. Studying cell differentiation and cell fate restrictions in these contexts can be done through lineage tracing experiments, which entail permanent labeling of a cell and all its progeny. Recent lineage experiments within the cardiovascular system have uncovered unexpected findings on cellular origins during organogenesis and cell plasticity during disease. For example, there is increasing evidence that multiple progenitor sources exist for a single cell type, and that cells have remarkable expansive capacities under disease settings. Here, we summarize some recent findings in the cardiovascular system and highlight where there is evidence that the underlying concepts are a widespread phenomenon used by other organ systems. Developmental Dynamics 246:328-335, 2017. © 2016 Wiley Periodicals, Inc.
了解细胞分化途径对于理解器官发育、体内平衡和疾病至关重要。在这些情况下研究细胞分化和细胞命运限制可以通过谱系追踪实验来完成，该实验需要对一个细胞及其所有后代进行永久性标记。最近在心血管系统内进行的谱系实验揭示了器官发生过程中细胞起源和疾病过程中细胞可塑性方面的意外发现。例如，越来越多的证据表明，单一细胞类型存在多种祖细胞来源，并且细胞在疾病状态下具有显著的增殖能力。在这里，我们总结了心血管系统的一些最新发现，并强调了有证据表明其潜在概念是其他器官系统广泛使用的一种现象的地方。《发育动力学》246:328 - 335，2017年。© 2016威利期刊公司。
