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智利雪貂体内猪流感病毒（H1N2）的特性与传播

Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile.

作者信息

Bravo-Vasquez Nicolás, Karlsson Erik A, Jimenez-Bluhm Pedro, Meliopoulos Victoria, Kaplan Bryan, Marvin Shauna, Cortez Valerie, Freiden Pamela, Beck Melinda A, Hamilton-West Christopher, Schultz-Cherry Stacey

出版信息

Emerg Infect Dis. 2017 Feb;23(2):241-251. doi: 10.3201/eid2302.161374.

DOI:10.3201/eid2302.161374
PMID:28098524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5324791/
Abstract

Phylogenetic analysis of the influenza hemagglutinin gene (HA) has suggested that commercial pigs in Chile harbor unique human seasonal H1-like influenza viruses, but further information, including characterization of these viruses, was unavailable. We isolated influenza virus (H1N2) from a swine in a backyard production farm in Central Chile and demonstrated that the HA gene was identical to that in a previous report. Its HA and neuraminidase genes were most similar to human H1 and N2 viruses from the early 1990s and internal segments were similar to influenza A(H1N1)pdm09 virus. The virus replicated efficiently in vitro and in vivo and transmitted in ferrets by respiratory droplet. Antigenically, it was distinct from other swine viruses. Hemagglutination inhibition analysis suggested that antibody titers to the swine Chilean H1N2 virus were decreased in persons born after 1990. Further studies are needed to characterize the potential risk to humans, as well as the ecology of influenza in swine in South America.

摘要

对流感血凝素基因（HA）的系统发育分析表明，智利的商业猪携带独特的人类季节性H1样流感病毒，但包括这些病毒特征在内的更多信息尚不可知。我们从智利中部一个后院养殖场的一头猪身上分离出流感病毒（H1N2），并证明其HA基因与之前报告中的相同。其HA和神经氨酸酶基因与20世纪90年代初的人类H1和N2病毒最为相似，内部片段与甲型流感病毒（H1N1）pdm09相似。该病毒在体外和体内均能有效复制，并通过呼吸道飞沫在雪貂中传播。在抗原性方面，它与其他猪病毒不同。血凝抑制分析表明，1990年后出生的人群对智利猪H1N2病毒的抗体滴度有所下降。需要进一步研究来确定该病毒对人类的潜在风险，以及南美洲猪流感的生态学特征。

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