Srinivas Sowmya, Tan Ou, Nittala Muneeswar G, Wu Jennifer L, Fawzi Amani A, Huang David, Sadda SriniVas R
*Doppler OCT Reading Center, Doheny Eye Institute, Los Angeles, California; †Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; ‡Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma; §Department of Ophthalmology, Northwestern University, Chicago, Illinois; and ¶Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Retina. 2017 Nov;37(11):2001-2007. doi: 10.1097/IAE.0000000000001479.
To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT).
Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained. Doppler OCT scans and accessory imaging data were imported into Doppler OCT of Retinal Circulation grading software to calculate TRBF and vascular parameters (e.g., venous and arterial cross-sectional area). Measurements were compared between cases and controls using independent t-tests.
Mean TRBF was 44.98 ± 9.80 (range: 30.18-64.58) µL/minute for normal eyes, 35.80 ± 10.48 (range: 20.69-49.56) µL/minute for eyes with severe NPDR, and 34.79 ± 10.61 (range: 16.77-48.9) µL/minute for eyes with PDR. Mean TRBF was significantly lower in eyes with severe NPDR (P = 0.01) and PDR (P = 0.003) than in normal eyes.
Total retinal blood flow was significantly lower in eyes with severe NPDR and PDR compared with normal eyes. Retinal blood flow determined by Doppler OCT may be a useful parameter for evaluating patients with DR.
使用多普勒傅里叶域光学相干断层扫描（FD-OCT）评估正常眼睛以及患有不同程度糖尿病视网膜病变（DR）的眼睛的视网膜血流测量情况。
将19名受试者的22只眼睛（其中10只患有严重非增殖性DR（NPDR），12只患有增殖性DR（PDR））与40名健康对照受试者的44只眼睛进行比较。所有眼睛均通过RTvue FD-OCT进行扫描。获取视盘彩色照片以及视神经乳头的立方体/容积扫描图像。将多普勒OCT扫描图像和辅助成像数据导入视网膜循环分级软件的多普勒OCT中，以计算总视网膜血流（TRBF）和血管参数（例如静脉和动脉横截面积）。使用独立t检验比较病例组和对照组之间的测量结果。
正常眼睛的平均TRBF为44.98±9.80（范围：30.18 - 64.58）微升/分钟，患有严重NPDR的眼睛为35.80±10.48（范围：20.69 - 49.56）微升/分钟，患有PDR的眼睛为34.79±10.61（范围：16.77 - 48.9）微升/分钟。患有严重NPDR（P = 0.01）和PDR（P = 0.003）的眼睛的平均TRBF显著低于正常眼睛。
与正常眼睛相比，患有严重NPDR和PDR的眼睛的总视网膜血流显著降低。通过多普勒OCT确定的视网膜血流可能是评估DR患者的一个有用参数。
