Srinivas Sowmya, Tan Ou, Wu Shuang, Nittala Muneeswar Gupta, Huang David, Varma Rohit, Sadda SriniVas R
Doppler OCT Reading Center, Doheny Eye Institute, Los Angeles, California, United States.
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
Invest Ophthalmol Vis Sci. 2015 Feb 10;56(3):1569-74. doi: 10.1167/iovs.14-15038.
To measure total retinal blood flow (TRBF) in normal, healthy Chinese Americans by using semi-automated analysis of Doppler Fourier-domain optical coherence tomography (FD-OCT) scans.
Two hundred sixty-six normal, healthy Chinese-American participants (266 eyes) were enrolled from The Chinese American Eye Study. All participants underwent complete ophthalmic examination, including best-corrected visual acuity, indirect ophthalmoscopy, and Doppler FD-OCT imaging, using the circumpapillary double circular scan protocol. Total retinal blood flow and other vascular parameters (e.g., venous and arterial cross-sectional area and their velocities) were calculated by using Doppler OCT of Retinal Circulation software. Associations between TRBF and other clinical parameters were assessed by using bivariate correlations and linear regression.
The mean age of study participants was 57.40 ± 5.60 (range, 50-82) years. The mean TRBF was 49.34 ± 10.08 (range, 27.17-78.08, 95% confidence interval: 25.98-69.10) μL/min. The mean venous area was 0.0548 (±0.0084) mm(2). Superior retinal hemispheric blood flow (25.50 ± 6.62 μL/min) was slightly greater than inferior retinal hemispheric blood flow (23.84 ± 7.19 μL/min, P = 0.008). The mean flow velocity was 15.16 ± 3.12 mm/s. There was a weak but significant negative correlation between TRBF and age (r = -0.15, P = 0.012). No significant correlation was found between TRBF and axial length (r = 0.11, P = 0.08). Retinal blood flow was not significantly correlated with any other clinical parameters, including body mass index, systolic blood pressure, diastolic blood pressure, and intraocular pressure.
Normal Doppler OCT-derived total retinal blood values in a Chinese-American population showed considerable variability, some of which was explained by age. These observations should help design future studies evaluating TRBF in populations with eye disease.
通过对多普勒傅里叶域光学相干断层扫描（FD-OCT）图像进行半自动分析，测量正常健康美籍华裔的视网膜总血流量（TRBF）。
从美籍华裔眼病研究中招募了266名正常健康的美籍华裔参与者（266只眼）。所有参与者均接受了全面的眼科检查，包括最佳矫正视力、间接检眼镜检查，以及采用视乳头周围双环扫描方案的多普勒FD-OCT成像。使用视网膜循环多普勒OCT软件计算视网膜总血流量和其他血管参数（如静脉和动脉横截面积及其流速）。通过双变量相关性分析和线性回归评估TRBF与其他临床参数之间的关联。
研究参与者的平均年龄为57.40±5.60（范围50 - 82）岁。平均TRBF为49.34±10.08（范围27.17 - 78.08，95%置信区间：25.98 - 69.10）μL/min。平均静脉面积为0.0548（±0.0084）mm²。视网膜上半球血流量（25.50±6.62 μL/min）略大于视网膜下半球血流量（23.84±7.19 μL/min，P = 0.008）。平均流速为15.16±3.12 mm/s。TRBF与年龄之间存在微弱但显著的负相关性（r = -0.15，P = 0.012）。未发现TRBF与眼轴长度之间存在显著相关性（r = 0.11，P = 0.08）。视网膜血流量与任何其他临床参数均无显著相关性，包括体重指数、收缩压、舒张压和眼压。
美籍华裔人群中通过正常多普勒OCT得出视网膜总血流量值存在相当大的变异性，其中部分变异可由年龄解释。这些观察结果将有助于设计未来评估眼病患者TRBF的研究。
