School of Stomatology, Jilin University , Changchun 130041, P. R. China.
First Hospital of Jilin University, Jilin University , Changchun 130021, P. R. China.
ACS Appl Mater Interfaces. 2017 Feb 1;9(4):3376-3387. doi: 10.1021/acsami.6b13911. Epub 2017 Jan 18.
Nanocomposites based on hollow Au nanostructures have gained considerable attention in theranostics applications because of their unique plasmonic structures and attractive physicochemical properties. The exploration of feasible and facile methods for constructing multifunctional nanocomposites combined with bioactive molecules is greatly needed for the development of multifunctional theranostics platforms. In this work, resveratrol, a natural polyphenol with antioxidant activity and cancer-chemopreventive propertyies is employed as the reducing agent cum coating agent for the surfactant-free preparation of Au@resveratrol hollow NPs (Au@Res HNPs). The as-prepared Au@Res HNPs were found to present good photothermal performance and chemical inhibition for cancer therapy. In vitro experiments indicated that the Au@Res HNPs can block cell cycles to inhibit cell division and lead to cell apoptosis after 808-nm laser irradiation. Because no toxic surfactants are introduced, the current protocol avoids the tedious surfactant separation and surface modification processes that are necessary for most theranostics materials.
基于中空金纳米结构的纳米复合材料在治疗应用中引起了相当大的关注，因为它们具有独特的等离子体结构和有吸引力的物理化学性质。为了开发多功能治疗平台，迫切需要探索构建多功能纳米复合材料的可行和简便方法，将其与生物活性分子结合。在这项工作中，白藜芦醇是一种具有抗氧化活性和抗癌化学预防特性的天然多酚，被用作无表面活性剂制备金@白藜芦醇中空 NPs（Au@Res HNPs）的还原剂和涂层剂。所制备的 Au@Res HNPs 表现出良好的光热性能和化学抑制作用，可用于癌症治疗。体外实验表明，Au@Res HNPs 在 808nm 激光照射后可以阻断细胞周期，抑制细胞分裂并导致细胞凋亡。由于没有引入有毒的表面活性剂，当前方案避免了大多数治疗材料所必需的繁琐的表面活性剂分离和表面改性过程。
