Poorgholy Nahid, Massoumi Bakhshali, Jaymand Mehdi
Department of Chemistry, Payame Noor University, P.O. BOX: 19395-3697, Tehran, Iran.
Department of Chemistry, Payame Noor University, P.O. BOX: 19395-3697, Tehran, Iran.
Int J Biol Macromol. 2017 Apr;97:654-661. doi: 10.1016/j.ijbiomac.2017.01.063. Epub 2017 Jan 15.
The aim of this study was to synthesis and characterization of a novel stimuli-responsive polymeric nanosystem for theranostic applications. For this purpose, starch was modified by itaconic anhydride to afford an itaconat-functionalized starch macromonomer (starch-IA). This macromonomer with carboxylic functional groups was subsequently adsorbed onto the surface of iron oxide nanoparticles (FeO NPs), and then copolymerized with N-isopropylacrylamide (NIPAAm) monomer via a 'free' radical initiated polymerization technique to produce a temperature-responsive magnetic nanohydrogel (MNHG). The chemical structures of all samples as representatives were characterized by means of Fourier transform infrared (FTIR) spectroscopy. The lower critical solution temperature (LCST), thermal responsibility, morphology, elemental composition, thermal stability, and magnetic properties of the synthesized MNHG were investigated. In addition, the methotrexate (MTX)-loading capacity (∼74%) and stimuli-responsive drug release ability of the synthesized MNHG were also evaluated. As results, we envision that the synthesized starch-g-PNIPAAm/FeO MNHG may be find theranostic applications, in part due to its smart physicochemical properties.
本研究的目的是合成并表征一种用于诊疗应用的新型刺激响应性聚合物纳米系统。为此，用衣康酸酐对淀粉进行改性，以得到衣康酸官能化的淀粉大分子单体（淀粉-IA）。随后，将这种带有羧基官能团的大分子单体吸附到氧化铁纳米颗粒（FeO NPs）的表面，然后通过“自由基”引发聚合技术与N-异丙基丙烯酰胺（NIPAAm）单体共聚，以制备温度响应性磁性纳米水凝胶（MNHG）。通过傅里叶变换红外（FTIR）光谱对所有作为代表的样品的化学结构进行了表征。研究了合成的MNHG的低临界溶液温度（LCST）、热响应性、形态、元素组成、热稳定性和磁性。此外，还评估了合成的MNHG的甲氨蝶呤（MTX）负载能力（约74%）和刺激响应性药物释放能力。结果表明，我们设想合成的淀粉-g-PNIPAAm/FeO MNHG可能会有诊疗应用，部分原因是其具有智能的物理化学性质。
