Xiong Zeng, Zhou Xia, Yue Shao-Jie
Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jan;19(1):121-125. doi: 10.7499/j.issn.1008-8830.2017.01.020.
With the development of treatment, the survival rate of premature infants has significantly increased, especially extremely premature infants and very low birth weight infants. This has led to an increase in incidence of bronchopulmonary dysplasia (BPD) year by year. BPD has been one of the most common respiratory system diseases in premature infants, especially the small premature infants. Arrested alveolar development is an important cause of BPD. Therefore, the mechanism of arrested alveolar development and the intervention measures for promoting alveolar development are the focuses of research on BPD. Selecting the appropriate animal model of BPD is the key to obtaining meaningful results in the basic research on BPD. Based on above, several common methods for establishing an animal model of BPD and the corresponding changes in pathophysiology are summarized and evaluated in order to provide a reference for selecting the appropriate animal model in studies on the pathogenesis, pathophysiology, and prevention and control strategies of BPD.
随着治疗手段的发展，早产儿尤其是极早产儿和极低出生体重儿的存活率显著提高。这导致支气管肺发育不良（BPD）的发病率逐年上升。BPD一直是早产儿尤其是小早产儿最常见的呼吸系统疾病之一。肺泡发育停滞是BPD的重要病因。因此，肺泡发育停滞的机制以及促进肺泡发育的干预措施是BPD研究的重点。选择合适的BPD动物模型是在BPD基础研究中获得有意义结果的关键。基于此，总结并评估了几种建立BPD动物模型的常用方法及其相应的病理生理变化，以便为BPD的发病机制、病理生理学以及防控策略研究中选择合适的动物模型提供参考。
