Buchen S Y, Richards S C, Solomon K D, Apple D J, Knight P M, Christ R, Pham L T, Nelson D L, Clayman H M, Karpinski L G
Allergan Medical Optics, Irvine, California.
J Cataract Refract Surg. 1989 Sep;15(5):545-53. doi: 10.1016/s0886-3350(89)80114-2.
The biocompatibility and fixation of a new silicone intraocular lens was evaluated in the cat eye. Following extracapsular lens extraction, 14 cats were implanted with a silicone lens (SLM 2/UV type) with polypropylene modified J loops in one eye and a poly(methyl methacrylate) (PMMA) lens (Perspex CQ) of a similar design in the fellow eye. Half the lenses were placed in the ciliary sulcus and half in the capsular bag. The eyes were evaluated for up to one year. Neither lens material showed any signs of toxicity clinically or histopathologically. Both lenses achieved stable fixation in the capsular bag; however, some inflammatory reaction and lens dislocation were noted with sulcus placement of both lens types. The amount of proteinaceous and cellular debris on the explanted silicone lenses was significantly less than that on the PMMA lenses as assessed with methylene blue staining. All retrieved lenses were optically clear and no significant change in the lens surface morphology, clarity and/or optical properties was observed.
在猫眼中评估了一种新型硅胶人工晶状体的生物相容性和固定情况。在进行囊外晶状体摘除术后，14只猫的一只眼睛植入了带有聚丙烯改良J袢的硅胶晶状体（SLM 2/UV型），另一只眼睛植入了设计相似的聚甲基丙烯酸甲酯（PMMA）晶状体（Perspex CQ）。一半的晶状体置于睫状沟，另一半置于囊袋内。对眼睛进行了长达一年的评估。两种晶状体材料在临床和组织病理学上均未显示出任何毒性迹象。两种晶状体在囊袋内均实现了稳定固定；然而，两种类型的晶状体置于睫状沟时均出现了一些炎症反应和晶状体脱位。用亚甲蓝染色评估，取出的硅胶晶状体上的蛋白质和细胞碎片量明显少于PMMA晶状体。所有取出的晶状体光学上均清晰，且未观察到晶状体表面形态、清晰度和/或光学性能有明显变化。
