Kulnig W, Menapace R, Skorpik C, Juchem M
First Department of Ophthalmology, University of Vienna Medical School, Austria.
J Cataract Refract Surg. 1989 Sep;15(5):510-8. doi: 10.1016/s0886-3350(89)80107-5.
We describe the histopathologic results of extracapsular lens extraction and silicone and poly(methyl methacrylate) (PMMA) intraocular lens (IOL) implantation in 36 rabbit eyes. Phase-contrast microscopy was used to examine precipitates on IOL surfaces and posterior capsules. Semithin and ultrathin sections were taken from the central cornea, anterior uvea, capsular bag, and retina near the posterior pole. The follow-up was one to 16 weeks. Silicone IOLs did not cause significantly less precipitation than PMMA IOLs. Precipitates consisted of spindle-shaped fibroblast-like cells, various forms of inflammatory cells and multinucleated giant cells, single melanophages, and irregularly arranged birefringent collagen fibers. Corneal endothelial edema was slightly more prominent in PMMA IOL implanted eyes. Significant retinal edema in the posterior pole area was not observed with either of the two lens types. Severe precipitation in the form of large clusters of pigment cells and inflammatory reactions seemed to depend on mechanical trauma (iris capture and lens dislocation) and individual animal reactions, but not on the lens type used.
我们描述了36只兔眼行囊外晶状体摘除及硅酮和聚甲基丙烯酸甲酯（PMMA）人工晶状体（IOL）植入后的组织病理学结果。利用相差显微镜检查IOL表面和后囊膜上的沉淀物。从中央角膜、前葡萄膜、囊袋以及后极附近的视网膜获取半薄切片和超薄切片。随访时间为1至16周。硅酮IOL引起的沉淀并不比PMMA IOL明显少。沉淀物包括梭形的成纤维细胞样细胞、各种形式的炎性细胞和多核巨细胞、单个巨噬细胞以及排列不规则的双折射胶原纤维。植入PMMA IOL的眼中角膜内皮水肿稍更明显。两种类型的晶状体均未观察到后极区明显的视网膜水肿。以大量色素细胞簇形式出现的严重沉淀和炎症反应似乎取决于机械创伤（虹膜嵌顿和晶状体脱位）以及个体动物的反应，而非所使用的晶状体类型。
