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Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease.脑脊液中脑源性神经营养因子浓度降低预示着从轻度认知障碍进展为阿尔茨海默病。
Neuromolecular Med. 2015 Sep;17(3):326-32. doi: 10.1007/s12017-015-8361-y. Epub 2015 Jul 3.
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Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory.脑源性神经营养因子Val66Met多态性及血浆脑源性神经营养因子与海马体积和记忆之间不存在关联。
Cogn Affect Behav Neurosci. 2015 Sep;15(3):625-43. doi: 10.3758/s13415-015-0343-x.
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Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol.基于 EADC-ADNI 协调的海马协议的海马分割训练标签。
Alzheimers Dement. 2015 Feb;11(2):175-83. doi: 10.1016/j.jalz.2014.12.002. Epub 2015 Jan 20.
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RBANS memory indices are related to medial temporal lobe volumetrics in healthy older adults and those with mild cognitive impairment.RBANS 记忆指数与健康老年人和轻度认知障碍者的内侧颞叶体积有关。
Arch Clin Neuropsychol. 2014 Jun;29(4):322-8. doi: 10.1093/arclin/acu012. Epub 2014 Apr 6.
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Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease.阿尔茨海默病患者的 BDNF 和炎症标志物水平升高。
J Psychiatr Res. 2014 Jun;53:166-72. doi: 10.1016/j.jpsychires.2014.01.019. Epub 2014 Feb 13.
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Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study.脑源性神经营养因子 Val66Met 对前驱期阿尔茨海默病记忆下降和海马萎缩的影响：一项初步研究。
PLoS One. 2014 Jan 27;9(1):e86498. doi: 10.1371/journal.pone.0086498. eCollection 2014.
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The neurotrophins and their role in Alzheimer's disease.神经生长因子及其在阿尔茨海默病中的作用。
Curr Neuropharmacol. 2011 Dec;9(4):559-73. doi: 10.2174/157015911798376190.
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Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults.血浆脑源性神经营养因子与老年人的与年龄相关的白质萎缩有关，但与认知功能无关。
PLoS One. 2012;7(4):e35217. doi: 10.1371/journal.pone.0035217. Epub 2012 Apr 16.
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The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.阿尔茨海默病所致痴呆的诊断：美国国家老龄化研究所-阿尔茨海默病协会工作组关于阿尔茨海默病诊断指南的建议。
Alzheimers Dement. 2011 May;7(3):263-9. doi: 10.1016/j.jalz.2011.03.005. Epub 2011 Apr 21.
10
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.阿尔茨海默病所致轻度认知障碍的诊断：美国国家老龄化研究所-阿尔茨海默病协会诊断指南工作组的建议。
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阿尔茨海默病所致轻度认知障碍和痴呆患者的脑源性神经营养因子血清水平及海马体积

Brain-Derived Neurotrophic Factor Serum Levels and Hippocampal Volume in Mild Cognitive Impairment and Dementia due to Alzheimer Disease.

作者信息

Borba Ericksen Mielle, Duarte Juliana Avila, Bristot Giovana, Scotton Ellen, Camozzato Ana Luiza, Chaves Márcia Lorena Fagundes

机构信息

Dementia Clinic, Neurology Service, Porto Alegre, Brazil; Postgraduate Program in Medical Sciences, School of Medicine, Porto Alegre, Brazil.

Radiology Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.

出版信息

Dement Geriatr Cogn Dis Extra. 2016 Dec 9;6(3):559-567. doi: 10.1159/000450601. eCollection 2016 Sep-Dec.

DOI:10.1159/000450601
PMID:28101102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5216193/
Abstract

BACKGROUND/AIMS: Hippocampal atrophy is a recognized biomarker of Alzheimer disease (AD) pathology. Serum brain-derived neurotrophic factor (BDNF) reduction has been associated with neurodegeneration. We aimed to evaluate BDNF serum levels and hippocampal volume in clinical AD (dementia and mild cognitive impairment [MCI]).

METHODS

Participants were 10 patients with MCI and 13 with dementia due to AD as well as 10 healthy controls. BDNF serum levels were determined by ELISA and volumetric measures with NeuroQuant®.

RESULTS

MCI and dementia patients presented lower BDNF serum levels than healthy participants; dementia patients presented a smaller hippocampal volume than MCI patients and healthy participants.

DISCUSSION

The findings support that the decrease in BDNF might start before the establishment of neuronal injury expressed by the hippocampal reduction.

摘要

背景/目的：海马萎缩是阿尔茨海默病（AD）病理的一种公认生物标志物。血清脑源性神经营养因子（BDNF）降低与神经退行性变有关。我们旨在评估临床AD（痴呆和轻度认知障碍[MCI]）患者的BDNF血清水平和海马体积。

方法

参与者包括10例MCI患者、13例AD所致痴呆患者以及10名健康对照者。采用酶联免疫吸附测定法（ELISA）测定BDNF血清水平，并使用NeuroQuant®进行体积测量。

结果

MCI和痴呆患者的BDNF血清水平低于健康参与者；痴呆患者的海马体积小于MCI患者和健康参与者。

讨论

研究结果支持BDNF的降低可能在海马萎缩所表达的神经元损伤出现之前就已开始。