Miyazaki Kunihiko, Satoh Hiroaki, Watanabe Hiroko, Shiozawa Toshihiro, Tamura Tomohiro, Kawaguchi Mio, Hizawa Nobuyuki
Department of Respiratory Medicine, Ryugasaki Saiseikai General Hospital, Ryugasaki, Ibaraki 301-0854, Japan.
Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito Kyodo General Hospital, Mito, Ibaraki 310-0015, Japan.
Biomed Rep. 2016 Dec;5(6):758-760. doi: 10.3892/br.2016.787. Epub 2016 Oct 19.
Bofutsushosan, a herbal (traditional Kampo) medicine, is administered to obese patients in North-East Asia. Bofutsushosan has been reported to exert various anti-obesity effects by stimulating the adipose tissue. The present study describes the case of a patient who developed a severe pulmonary injury that was potentially associated with bofutsushosan therapy. A 52-year-old woman was admitted to Mito Medical Center, University of Tsukuba, Mito Kyodo General Hospital (Mito, Japan) due to progressive dyspnea. Two months previously, bofutsushosan had been newly prescribed for her obesity. Bilateral ground-glass opacities and progressive respiratory deterioration suggested respiratory failure due to a therapeutic agent-induced lung injury. With discontinuation of bofutsushosan and the administration of a corticosteroid, an improvement in her respiratory condition was achieved, although sequelae remained in certain areas of the lungs. Resumption of other therapeutic agents did not reinduce the lung injury. Therefore, a diagnosis of bofutsushosan-induced lung injury was made. Although bofutsushosan-induced lung injury is particularly rare, clinicians should consider it when bofutsushosan is used.
防风通圣散是一种草药（传统汉方）药，在东北亚地区用于肥胖患者。据报道，防风通圣散通过刺激脂肪组织发挥多种抗肥胖作用。本研究描述了一例可能与防风通圣散治疗相关的严重肺损伤患者的病例。一名52岁女性因进行性呼吸困难入住筑波大学附属医院水户医疗中心、水户协同综合医院（日本水户）。两个月前，她因肥胖开始新服用防风通圣散。双侧磨玻璃影和进行性呼吸恶化提示治疗药物性肺损伤导致呼吸衰竭。停用防风通圣散并给予皮质类固醇后，她的呼吸状况有所改善，尽管肺部某些区域仍有后遗症。恢复使用其他治疗药物并未再次诱发肺损伤。因此，诊断为防风通圣散所致肺损伤。尽管防风通圣散所致肺损伤极为罕见，但在使用防风通圣散时临床医生应予以考虑。
