Kwon-Chung Kyung J, Bennett John E, Wickes Brian L, Meyer Wieland, Cuomo Christina A, Wollenburg Kurt R, Bicanic Tihana A, Castañeda Elizabeth, Chang Yun C, Chen Jianghan, Cogliati Massimo, Dromer Françoise, Ellis David, Filler Scott G, Fisher Matthew C, Harrison Thomas S, Holland Steven M, Kohno Shigeru, Kronstad James W, Lazera Marcia, Levitz Stuart M, Lionakis Michail S, May Robin C, Ngamskulrongroj Popchai, Pappas Peter G, Perfect John R, Rickerts Volker, Sorrell Tania C, Walsh Thomas J, Williamson Peter R, Xu Jianping, Zelazny Adrian M, Casadevall Arturo
Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
mSphere. 2017 Jan 11;2(1). doi: 10.1128/mSphere.00357-16. eCollection 2017 Jan-Feb.
Cryptococcosis is a potentially lethal disease of humans/animals caused by and . Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that be divided into two species and into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using " species complex" and " species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.
隐球菌病是由[具体病原体]引起的一种对人类/动物具有潜在致死性的疾病。这两个物种之间的区分基于表型和基因型特征。最近,基于对115株分离株的系统发育分析,有人提议将[某物种]分为两个物种,将[另一物种]分为五个物种。虽然这一提议增加了我们对隐球菌病病原体的遗传多样性和种群结构的了解,但已公布的2606株菌株的基因型所显示的遗传多样性已超过七个物种所能涵盖的范围。在这个时候将每个进化枝命名为一个单独的物种将导致命名的持续不稳定。由于进化枝之间没有生物学差异,而且对于仅靠DNA序列如何界定一个物种也没有达成共识,我们建议使用“[物种名称]复合群”和“[物种名称]复合群”作为一个实际的中间步骤,而不是创建更多的物种。这种策略在不造成混淆的情况下认可了遗传多样性。