Verrotti Alberto, D'Alonzo Renato, Rinaldi Victoria Elisa, Casciato Sara, D'Aniello Alfredo, Di Gennaro Giancarlo
Department of Pediatrics, Ospedale S. Salvatore, L'Aquila University School of Medicine, University of L'Aquila, L'Aquila, 67100, Italy.
Department of Paediatrics, University of Perugia, Perugia, Italy.
World J Pediatr. 2017 Apr;13(2):106-111. doi: 10.1007/s12519-017-0006-9. Epub 2017 Jan 15.
Recent studies have shown a possible coexistence of absence seizures with other forms of epilepsy. The purpose of this study was to ascertain the possible contemporary or subsequent presence of childhood absence epilepsy (CAE) and benign epilepsy with centro-temporal spikes (BECTS) in pediatric epileptic patients.
A PubMed systematic search indexed for MEDLINE, PubMed and EMBASE was undertaken to identify studies in children including articles written between 1996 and 2015. Retrospective studies, meta-analysis and case reports were included. The list of references of all the relevant articles was also studied. The date of our last search was December 2015.
Review of the literature revealed 19 cases, 8 females and 11 males, reporting a consecutive or contemporary coexistence of CAE and BECTS within the same patients. Patient's age ranged between 4 and 12 years. Three out of 19 patients presented concomitant features of both syndromes, whereas 16 patients experienced the two syndromes at different times.
BECTS and CAE may be pathophysiologically related, and the two epileptic phenotypes may indicate a neurobiological continuum. Further studies are needed to elucidate a probable genetic or functional link between partial and primarily generalized electro-clinical patterns in idiopathic childhood epilepsies.
近期研究表明失神发作可能与其他形式的癫痫共存。本研究的目的是确定小儿癫痫患者中儿童失神癫痫（CAE）和伴中央颞区棘波的良性癫痫（BECTS）可能同时存在或随后出现的情况。
对MEDLINE、PubMed和EMBASE索引的PubMed进行系统检索，以识别有关儿童的研究，包括1996年至2015年期间撰写的文章。纳入回顾性研究、荟萃分析和病例报告。还研究了所有相关文章的参考文献列表。我们最后一次检索的日期是2015年12月。
文献回顾发现19例病例，其中女性8例，男性11例，报告同一患者中CAE和BECTS连续或同时存在。患者年龄在4至12岁之间。19例患者中有3例同时出现两种综合征的特征，而16例患者在不同时间出现这两种综合征。
BECTS和CAE可能在病理生理上相关，这两种癫痫表型可能表明一种神经生物学连续体。需要进一步研究以阐明特发性儿童癫痫中部分性和原发性全身性电临床模式之间可能的遗传或功能联系。
