Chen Rui, Yan Jinchuan, Liu Peijing, Wang Zhongqun, Wang Cuiping, Zhong Wei, Xu Liangjie
a Department of Cardiology , Affiliated Hospital of Jiangsu University , Zhenjiang , Jiangsu , China.
Cell Cycle. 2017 Mar 19;16(6):508-514. doi: 10.1080/15384101.2017.1281485. Epub 2017 Jan 19.
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor about 3 decades ago and was not well studied until the development of immunosuppressant. Numerous studies confirm that calcineurin/NFAT signaling is very important in the development of vasculature and cardiovascular system during embryogenesis and is involved in the development of vascular diseases such as hypertension, atherosclerosis and restenosis. Recent studies demonstrated that NFAT proteins also regulate immune response and vascular cells in the pulmonary microenvironment. In this review, we will discuss how different NFAT isoforms contribute to pulmonary vascular remodeling and potential new therapeutic targets for treating pulmonary arterial hypertension.
活化T细胞核因子（NFAT）大约在30年前首次被鉴定为一种转录因子，直到免疫抑制剂出现后才得到充分研究。大量研究证实，钙调神经磷酸酶/NFAT信号在胚胎发育过程中对脉管系统和心血管系统的发育非常重要，并参与高血压、动脉粥样硬化和再狭窄等血管疾病的发生发展。最近的研究表明，NFAT蛋白也在肺微环境中调节免疫反应和血管细胞。在这篇综述中，我们将讨论不同的NFAT亚型如何促进肺血管重塑以及治疗肺动脉高压的潜在新治疗靶点。
