突触小泡的易释放池。
The readily releasable pool of synaptic vesicles.
作者信息
Kaeser Pascal S, Regehr Wade G
机构信息
Department of Neurobiology, Harvard Medical School, United States.
出版信息
Curr Opin Neurobiol. 2017 Apr;43:63-70. doi: 10.1016/j.conb.2016.12.012. Epub 2017 Jan 16.
Abstract
Each presynaptic bouton is densely packed with many vesicles, only a small fraction of which are available for immediate release. These vesicles constitute the readily releasable pool (RRP). The RRP size, and the probability of release of each vesicle within the RRP, together determine synaptic strength. Here, we discuss complications and recent advances in determining the size of the physiologically relevant RRP. We consider molecular mechanisms to generate and regulate the RRP, and discuss the relationship between vesicle docking and the RRP. We conclude that many RRP vesicles are docked, that some docked vesicles may not be part of the RRP, and that undocked vesicles can contribute to the RRP by rapid recruitment to unoccupied, molecularly activated ready-to-release sites.
摘要
每个突触前终扣都密集地填充着许多囊泡，其中只有一小部分可用于即时释放。这些囊泡构成了易释放池（RRP）。RRP的大小以及RRP内每个囊泡的释放概率共同决定了突触强度。在这里，我们讨论在确定生理相关RRP大小方面的复杂性和最新进展。我们考虑产生和调节RRP的分子机制，并讨论囊泡对接与RRP之间的关系。我们得出的结论是，许多RRP囊泡是对接的，一些对接的囊泡可能不是RRP的一部分，并且未对接的囊泡可以通过快速募集到未被占据的、分子激活的准备释放位点来对RRP做出贡献。
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