Svolos Vaios, Gerasimidis Konstantinos, Buchanan Elaine, Curtis Lee, Garrick Vikki, Hay Jacqueline, Laird Susan, Munro Joanna, Gaya Daniel R, Russell Richard K, Hansen Richard
Human Nutrition, School of Medicine, Dentistry & Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children, Glasgow, UK.
BMC Gastroenterol. 2017 Jan 19;17(1):14. doi: 10.1186/s12876-016-0564-7.
Diet is strongly associated with the aetiology of Crohn's Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of EEN and alternative novel, solid food-based diets (SFDs) expressed by paediatric patients with CD, previously treated with EEN and their parents.
This anonymous questionnaire surveyed families of CD patients treated with EEN over 1 year. Two questionnaire forms were completed; one asking the patients' opinions and another referring to their main carer. This questionnaire explored participants' demographic characteristics; acceptability of a repeat EEN course to treat a future flare (EEN repeat); their opinion on how difficult EEN would be compared to an example SFD; and their intention to participate in a future clinical trial assessing the therapeutic efficacy of an SFD in CD.
Forty-one families of CD patients were approached with 29 sending replies (71%). Most of our participants were positive on completing another EEN course, however the majority would choose an SFD alternative (Patients:66, Parents:72%). Both patients and their parents rated EEN to be more difficult to adhere to compared to an example SFD (p < 0.05), and their ratings were strongly correlated (EEN:r = 0.83, SFD:r = 0.75, p < 0.001). The majority of our respondents would agree to participate in a clinical trial assessing an SFD's effectiveness (Patients:79, Parents:72%) for the management of active CD.
While patients with CD and their families would accept an EEN repeat, the majority would prefer an SFD alternative. CD families surveyed are supportive of the development of solid food-based dietary treatments.
饮食与克罗恩病（CD）的病因密切相关，全肠内营养（EEN）是儿童CD的主要诱导治疗方法。本研究探讨了曾接受EEN治疗的儿童CD患者及其父母对EEN及新型固体食物替代饮食（SFD）的看法。
本匿名问卷对接受EEN治疗超过1年的CD患者家庭进行了调查。完成了两份问卷；一份询问患者的意见，另一份询问其主要照顾者的意见。该问卷探讨了参与者的人口统计学特征；对未来复发时重复进行EEN治疗疗程的接受度（EEN重复）；他们对EEN与一种示例SFD相比难度如何的看法；以及他们参与未来评估SFD对CD治疗效果的临床试验的意愿。
共联系了41个CD患者家庭，29个家庭回复（71%）。我们的大多数参与者对完成另一个EEN疗程持积极态度，然而大多数人会选择SFD替代方案（患者：66%，父母：72%）。患者及其父母都认为与一种示例SFD相比，EEN更难坚持（p<0.05），且他们的评分高度相关（EEN：r = 0.83，SFD：r = 0.75，p<0.001）。我们的大多数受访者会同意参与评估SFD对活动性CD管理效果的临床试验（患者：79%，父母：72%）。
虽然CD患者及其家庭会接受重复进行EEN治疗，但大多数人更喜欢SFD替代方案。接受调查的CD患者家庭支持开发基于固体食物的饮食治疗方法。
