Basic Parameters of Blood Count as Prognostic Factors for Renal Cell Carcinoma.

. Renal cell carcinoma is the most common type of kidney cancer. Taking account of morbidity and mortality increase, it is evident that searching for independent prognostic factors is needed. . The aim of the study was to analyze routinely performed blood parameters as potential prognostic factors for kidney cancer. . We have retrospectively reviewed the records of 230 patients treated for renal cell carcinoma in the years 2000-2006. Preoperative blood parameters, postoperative histopathological results, and staging and grading were performed. To estimate the risk of tumor recurrence and cancer specific mortality (CSM) within five years of follow-up, uni- and multivariate Cox and regression analyses were used. To assess the quality of classifiers and to search for the optimal cut-off point, the ROC curve was used. . T stage of the tumor metastasis is the most important risk factor for early recurrence and cancer specific mortality ( < 0.001). The preoperative platelet count (PLT) above 351 × 10/uL (95.3%; 55.1%) and AUC of 77% are negative prognostic factors and correlate with increased cancer specific mortality (CSM) during the five-year follow-up ( < 0.001). Increased risk of local recurrence was observed for PLT above 243.5 × 10/ul (59%; 88%) and AUC of 80% ( = 0.001). The opposite was observed in the mean platelets volume (MPV) for cancer specific mortality (CSM). The cut-off point for the MPV was 10.1 fl (75.4%; 55.1%) and for the AUC is of 68.1% ( = 0.047). . Many analyzed parameters in univariate regressions reached statistical significance and could be considered as potential prognostic factors for ccRCC. In multivariate analysis, only T stage, platelet count (PLT), and mean platelet volume (MPV) correlated with CSM or recurrent ccRCC.