Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, No. 150 Haping ST, Nangang District, Harbin, Heilongjiang, 150081, China.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Int J Clin Oncol. 2017 Dec;22(6):1076-1080. doi: 10.1007/s10147-017-1158-2. Epub 2017 Jun 29.
Renal cell carcinoma (RCC) is the third most common genitourinary cancer. Activated platelets play a pivotal role in cancer development and progression. Altered mean platelet volume (MPV) has been reported in several malignancies. The aim of the present study was to investigate the association of MPV with RCC.
The study consisted of 145 patients with RCC, 110 patients with benign renal tumor and 132 healthy control subjects between January 2015 and December 2015. All participants' clinical and laboratory characteristics at initial diagnosis were collected. The odds ratios (ORs) for RCC were calculated using multivariate logistic regression analysis after adjusting for confounding variables across MPV quartiles.
The patients with RCC had decreased pre-operative MPV compared to the patients with benign renal tumor and healthy control subjects. Furthermore, pre-operative MPV was reduced in benign renal tumor compared with healthy control subjects. Surgical tumor resection resulted in a significant increase in MPV levels (8.7 fL vs. 9.0 fL; p = 0.011). After adjusting for other risk factors, the ORs (95% CIs) for RCC in each MPV quartile were 25.725 (7.556-87.585), 7.447 (2.701-20.537), 0.703 (0.245-2.019), and 1.000, respectively.
RCC patients have remarkably reduced MPV compared to patients with benign renal tumor and healthy control subjects. Moreover, decreased MPV was independently associated with RCC. Our results suggest that detection of MPV may be useful to assess the risk of RCC.
肾细胞癌（RCC）是第三大常见的泌尿生殖系统癌症。活化的血小板在癌症的发生和发展中起着关键作用。已有报道称，几种恶性肿瘤存在平均血小板体积（MPV）改变。本研究旨在探讨MPV 与 RCC 的关系。
该研究纳入了 2015 年 1 月至 2015 年 12 月期间的 145 例 RCC 患者、110 例良性肾肿瘤患者和 132 例健康对照者。收集所有参与者初诊时的临床和实验室特征。采用多变量 logistic 回归分析调整 MPV 四分位区间的混杂变量后，计算 RCC 的比值比（OR）。
与良性肾肿瘤和健康对照组相比，RCC 患者术前的 MPV 降低。此外，与健康对照组相比，良性肾肿瘤患者的术前 MPV 降低。手术肿瘤切除导致 MPV 水平显著升高（8.7 fL 比 9.0 fL；p=0.011）。在调整其他危险因素后，每个 MPV 四分位区间的 RCC 比值比（95%CI）分别为 25.725（7.556-87.585）、7.447（2.701-20.537）、0.703（0.245-2.019）和 1.000。
与良性肾肿瘤和健康对照组相比，RCC 患者的 MPV 明显降低。此外，MPV 降低与 RCC 独立相关。我们的研究结果表明，检测 MPV 可能有助于评估 RCC 的风险。
