Department of Gastroenterology, Shanghai Jinshan Branch of the Sixth People's Hospital, Health Road No. 147, Zhujing Town, Jinshan District, Shanghai, 201500, China.
Clin Transl Oncol. 2021 Apr;23(4):731-737. doi: 10.1007/s12094-020-02462-z. Epub 2020 Aug 12.
The purpose of this study was to conduct a retrospective study about the clinical effects of endoscopic mucosal dissection on the treatment of early esophagogastric precancerous lesions.
A total of 132 patients with early esophagogastric precancerous lesions who were diagnosed and treated with concurrent surgery in our hospital from January 2018 to December 2019 were included in this retrospective study. Patients were divided into endoscopic mucosal resection (EMR) group (n = 58) and endoscopic submucosal dissection (ESD) group (n = 74) according to different surgical methods. The data in the two groups were compared and analyzed in terms of surgical indicators, treatment status and incidence of postoperative complications.
There were statistically significant differences between the two groups in the whole block cutting rate, fractional cutting rate and complete cutting rate (P < 0.05). The mean operation time of ESD group was significantly longer than that of EMR group (P < 0.05). There were no significant differences in the intraoperative bleeding rate, blood loss, average specimen area, length of hospital stay and treatment cost between the two groups (P > 0.05). The incidence and recurrence of postoperative complications, including bleeding, perforation and stenosis in the two groups, were observed within 1 year of postoperative follow-up. The incidence of complications in ESD group was slightly higher than that in EMR group, and the local recurrence rate in ESD group was lower than that in EMR group (P > 0.05).
ESD is an alternative surgical treatment for patients with early esophagogastric precancerous lesions.
本研究旨在对内镜黏膜下剥离术治疗早期食管胃前病变的临床效果进行回顾性研究。
回顾性分析 2018 年 1 月至 2019 年 12 月在我院经手术同步诊断并治疗的 132 例早期食管胃前病变患者的临床资料，根据手术方法的不同将患者分为内镜黏膜切除术（EMR）组（n=58）和内镜黏膜下剥离术（ESD）组（n=74）。比较两组患者的手术指标、治疗情况及术后并发症发生情况。
两组整块切除率、分片切除率、完整切除率比较，差异有统计学意义（P<0.05）；ESD 组手术时间明显长于 EMR 组，差异有统计学意义（P<0.05）；两组术中出血量、术中出血量、平均标本面积、住院时间及治疗费用比较，差异无统计学意义（P>0.05）。术后 1 年内随访观察两组患者的出血、穿孔及狭窄等并发症的发生及复发情况，ESD 组并发症发生率略高于 EMR 组，ESD 组局部复发率低于 EMR 组，但差异均无统计学意义（P>0.05）。
ESD 是治疗早期食管胃前病变的一种可选手术治疗方法。
