Kataoka Yu, Andrews Jordan, Puri Rishi, Psaltis Peter J, Nicholls Stephen J
aDepartment of Cardiovascular Medicine National Cerebral & Cardiovascular Centre, Suita, Japan bHeart Health, South Australian Health & Medical Research Institute, University of Adelaide, Adelaide, Australia cQuebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.
Curr Opin Endocrinol Diabetes Obes. 2017 Apr;24(2):122-132. doi: 10.1097/MED.0000000000000317.
To summarize the impact of lowering LDL-C on plaque progression, microstructures and compositions.
Low-density lipoprotein cholesterol (LDL-C) is a major therapeutic target to prevent atherosclerotic cardiovascular disease. Intravascular imaging has elucidated antiatherosclerotic effects of lowering LDL-C in vivo. Intensive control of LDL-C with a statin has been shown to slow plaque progression and induce its regression if very low LDL-C level is achieved. This therapeutic approach has been also demonstrated to modulate plaque microstructures and compositions. These mechanistic insights on intravascular imaging support the benefit of lowering LDL-C in achieving better cardiovascular outcomes.
Lowering LDL-C level has become the first-line therapy in the primary and secondary prevention settings. The effects of lowering LDL-C on plaque progression, microstructures and compositions will be reviewed in this article.
总结降低低密度脂蛋白胆固醇（LDL-C）对斑块进展、微观结构和成分的影响。
低密度脂蛋白胆固醇（LDL-C）是预防动脉粥样硬化性心血管疾病的主要治疗靶点。血管内成像已阐明降低LDL-C在体内的抗动脉粥样硬化作用。使用他汀类药物强化控制LDL-C已被证明可减缓斑块进展，并且如果能达到极低的LDL-C水平还可促使斑块消退。这种治疗方法也已被证明可调节斑块的微观结构和成分。这些血管内成像的机制性见解支持降低LDL-C对实现更好心血管结局的益处。
降低LDL-C水平已成为一级和二级预防中的一线治疗方法。本文将综述降低LDL-C对斑块进展、微观结构和成分的影响。
