Avidor-Reiss Tomer, Ha Andrew, Basiri Marcus L
University of Toledo, Department of Biological Sciences, Toledo, Ohio 43606.
Cold Spring Harb Perspect Biol. 2017 Aug 1;9(8):a028142. doi: 10.1101/cshperspect.a028142.
The cilium is an elongated and continuous structure that spans two major subcellular domains. The cytoplasmic domain contains a short centriole, which serves to nucleate the main projection of the cilium. This projection, known as the axoneme, remains separated from the cytoplasm by a specialized gatekeeping complex within a ciliary subdomain called the transition zone. In this way, the axoneme is compartmentalized. Intriguingly, however, this general principle of cilium biology is altered in the sperm cells of many animals, which instead contain a cytoplasmic axoneme domain. Here, we discuss the hypothesis that the formation of specialized sperm giant centrioles and cytoplasmic cilia is mediated by the migration of the transition zone from its typical location as part of a structure known as the annulus and examine the intrinsic properties of the transition zone that may facilitate its migratory behavior.
纤毛是一种细长且连续的结构，跨越两个主要的亚细胞区域。细胞质区域包含一个短的中心粒，它用于使纤毛的主要突起成核。这个突起被称为轴丝，在一个称为过渡区的纤毛亚区域内，通过一个特殊的守门复合体与细胞质保持分离。通过这种方式，轴丝被分隔开来。然而，有趣的是，许多动物的精子细胞改变了这种纤毛生物学的一般原理，它们反而含有一个细胞质轴丝区域。在这里，我们讨论一种假说，即特殊精子巨型中心粒和细胞质纤毛的形成是由过渡区从其作为称为环的结构一部分的典型位置迁移介导的，并研究可能促进其迁移行为的过渡区的内在特性。
