Departamento de Bioquímica, Faculdade de Medicina, Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal.
J Tissue Eng Regen Med. 2018 Jan;12(1):240-251. doi: 10.1002/term.2405. Epub 2017 May 23.
Fibroblasts constitute a dynamic and versatile population of cells of mesenchymal origin, implicated in both regenerative strategies and pathological conditions. Despite being frequently associated to disease development, particularly through the establishment of fibrotic tissue, fibroblasts hold great potential for tissue engineering and regenerative medicine applications. They are responsible for synthesizing and depositing extracellular matrix components, allowing other cells to settle and migrate along a three-dimensional support and thereby generating an organ-specific architecture. Additionally, they produce bioactive molecules that are involved in several physiological processes, including angiogenesis and tissue repair. Although there seems to be much still to unveil about these fascinating cells they have been attracting increasing interest and are now being intensively explored as a cell source to develop bioengineered tissue constructs or to improve stem cell-based technologies. This review intends to highlight the potential of fibroblasts in orchestrating tissue regeneration, as well as to contribute to uncover uncharted prospective applications of these cells. Copyright © 2017 John Wiley & Sons, Ltd.
成纤维细胞是一种具有动态和多功能的间充质来源细胞群体，涉及再生策略和病理状况。尽管它们经常与疾病的发展有关，特别是通过纤维化组织的建立，但成纤维细胞在组织工程和再生医学应用中有很大的潜力。它们负责合成和沉积细胞外基质成分，允许其他细胞在三维支架上定居和迁移，从而产生特定于器官的结构。此外，它们还产生生物活性分子，参与包括血管生成和组织修复在内的多种生理过程。尽管这些迷人的细胞似乎还有很多未解之谜，但它们已经引起了越来越多的关注，现在正被作为一种细胞来源来开发生物工程组织构建体或改进基于干细胞的技术进行深入研究。这篇综述旨在强调成纤维细胞在协调组织再生方面的潜力，并为揭示这些细胞的未知潜在应用做出贡献。版权所有©2017 年约翰威立父子公司。
