Vassiliou Leandros-Vassilios, Lalabekyan Bagrat, Jay Amrita, Liew Colin, Whelan Jeremy, Newman Laurence, Kalavrezos Nicholas
University College London Hospital (UCLH), London, UK.
University College London Hospital (UCLH), London, UK.
Oral Oncol. 2017 Feb;65:16-22. doi: 10.1016/j.oraloncology.2016.12.005. Epub 2016 Dec 18.
Sarcomas are tumours of mesenchymal origin, accounting for 1% of all malignancies.
This is a retrospective analysis of 107 head and neck sarcoma cases, treated over a period of thirteen years.
Fifty-four patients had with craniofacial bone sarcomas (BSs) (male: 33; female: 21) with high grade osteosarcoma being the most predominant type. The soft tissue sarcomas (STS) (53 patients; male: 28, female: 25) were histologically diverse with rhabdomyosarcomas and myxofibrosarcomas being the predominant types. The majority of BSs were managed with neoadjuvant chemotherapy followed by surgery, whereas in STSs treatment included predominantly surgery followed by radiotherapy. Overall survival estimates were 79% at 2years and 64% at 5years (mean follow-up period was 48months).
The mesenchymal origin of sarcomas, the pattern of disease spread and the different extent of cancellous bone infiltration in contrast to epithelial tumours, dictate distinct principles for surgical clearance.
肉瘤是间叶组织来源的肿瘤，占所有恶性肿瘤的1%。
这是一项对107例头颈部肉瘤病例进行的回顾性分析，这些病例在13年的时间里接受了治疗。
54例患者患有颅面部骨肉瘤（BSs）（男性33例；女性21例），其中高级别骨肉瘤是最主要的类型。软组织肉瘤（STS）（53例患者；男性28例，女性25例）在组织学上具有多样性，横纹肌肉瘤和黏液纤维肉瘤是主要类型。大多数骨肉瘤采用新辅助化疗后手术治疗，而软组织肉瘤的治疗主要包括手术，然后是放疗。总体生存率估计2年时为79%，5年时为64%（平均随访期为48个月）。
与上皮性肿瘤相比，肉瘤的间叶组织起源、疾病扩散模式以及松质骨浸润程度不同，决定了手术切除的不同原则。
