Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil.
Eur Arch Otorhinolaryngol. 2020 May;277(5):1473-1480. doi: 10.1007/s00405-020-05834-x. Epub 2020 Feb 4.
This study aimed to analyze the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas diagnosed in a reference center in the Brazilian Northeast.
This retrospective cohort study reviewed the clinical records of patients with head and neck sarcomas. Epidemiologic data consisted in clinical location, age, gender, histopathological diagnosis, clinical TNM staging and treatment. Outcome variables were local recurrence and survival. The statistical analyses were performed by a binary logistic regression analysis. The survival analysis was assessed through the Kaplan-Meier curve.
Sixty-nine patients with head and neck sarcomas (male 39; female 30) were analyzed. The most common histologic subtypes were rhabdomyosarcoma, dermatofibrosarcoma, and pleomorphic sarcoma. The mean age of the patients at the time of diagnosis was 38.1 years old. A total of 31 patient died (sarcoma-related death) up to the end of the follow-up, with a mean follow-up rate of 1.63 years. A multivariate analysis revealed that anatomical site, treatment modality, histopathological diagnosis, and clinical stage of the disease were associated with specific survival, reaching statistical significance.
This study demonstrates the impact of important clinical-pathological parameters on the overall prognosis of head and neck sarcomas.
本研究旨在分析巴西东北部某一参考中心诊断的头颈部肉瘤的人口统计学、临床病理、治疗和生存特征。
本回顾性队列研究回顾了头颈部肉瘤患者的临床记录。流行病学数据包括临床部位、年龄、性别、组织病理学诊断、临床 TNM 分期和治疗。结局变量为局部复发和生存。统计分析采用二项逻辑回归分析。生存分析通过 Kaplan-Meier 曲线进行评估。
共分析了 69 例头颈部肉瘤患者（男性 39 例，女性 30 例）。最常见的组织学亚型是横纹肌肉瘤、皮肤纤维肉瘤和多形性肉瘤。患者诊断时的平均年龄为 38.1 岁。共有 31 例患者死亡（与肉瘤相关的死亡），随访至随访结束，平均随访率为 1.63 年。多变量分析显示，解剖部位、治疗方式、组织病理学诊断和疾病临床分期与特定生存相关，达到统计学意义。
本研究表明了重要的临床病理参数对头颈部肉瘤整体预后的影响。
