伊朗一家大型癌症中心头颈肉瘤的患病率——一项为期10年的研究
Prevalence of Head and Neck Sarcoma in a Major Cancer Center in Iran- A 10-Year Study.
作者信息
Atarbashi-Moghadam Saede, Emami Razavi Amir Nader, Salehi Zalani Saman
机构信息
Department of Oral and Maxillofacial Pathology, Dental School of Shahid Beheshti University, Tehran, Iran.
PhD Iran National Tumor Bank, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Otorhinolaryngol. 2019 Mar;31(103):97-102.
INTRODUCTION
Sarcomas are rare malignancies with aggressive biological behavior. They are categorized into soft and hard tissue types. The main objective of this study was to analyze the prevalence of head and neck sarcomas (HNS) among the Iranian population.
MATERIALS AND METHODS
The pathology files derived from Iran National Tumor Bank of Cancer Institute in Imam Khomeini Hospital, affiliated to Tehran University of Medical Sciences, Tehran, Iran, served as the source of the materials for this study. All cases diagnosed with head and neck sarcoma were included in the study. The recorded data included the patient's age, gender, tumor location, and rates of recurrence and metastasis.
RESULTS
Investigation of the pathology files of the patients referring to the center under study during a 10-year period resulted in the identification of 183 HNS cases, 96.17% of which were primary. Generally, the prevalence of this disease was at its highest level in patients within the age range of 30-60 years with a male to female ratio of 1.4. The recurrence and metastasis rates of HNS were 32.38% and 5%, respectively. Osteosarcoma was detected as the most common type of sarcoma. Soft tissue sarcomas constituted 69.3% of the lesions with a male predilection. The patients afflicted with this type of sarcoma had a mean age of 45.88 years. Furthermore, hard tissue sarcomas comprised 30.68% of the sarcoma cases with a mean age of 36.22 years and a female predilection. The commonest lesion was osteosarcoma, and the most typical location was the mandible.
CONCLUSION
In the current study, head and neck sarcomas were most often observed in patients within the age range of 30-60 years with a male predilection. Osteosarcoma was identified as the most common type of sarcoma. Studies addressing rare lesions with a large sample size facilitate the recognition of the demographic data and histopathologic variation which may contribute to a correct diagnosis.
引言
肉瘤是具有侵袭性生物学行为的罕见恶性肿瘤。它们分为软组织和硬组织类型。本研究的主要目的是分析伊朗人群中头颈部肉瘤（HNS）的患病率。
材料与方法
本研究的材料来源是伊朗德黑兰医科大学附属伊玛目霍梅尼医院伊朗国家肿瘤库的病理档案。所有诊断为头颈部肉瘤的病例均纳入研究。记录的数据包括患者的年龄、性别、肿瘤位置以及复发和转移率。
结果
对在10年期间转诊至该研究中心的患者病理档案进行调查，共识别出183例头颈部肉瘤病例，其中96.17%为原发性。一般来说，该疾病在30至60岁患者中患病率最高，男女比例为1.4。头颈部肉瘤的复发率和转移率分别为32.38%和5%。骨肉瘤被检测为最常见的肉瘤类型。软组织肉瘤占病变的69.3%，男性更易患病。患这种类型肉瘤的患者平均年龄为45.88岁。此外，硬组织肉瘤占肉瘤病例的30.68%，平均年龄为36.22岁，女性更易患病。最常见的病变是骨肉瘤，最典型的部位是下颌骨。
结论
在本研究中，头颈部肉瘤最常出现在30至60岁、男性更易患病的患者中。骨肉瘤被确定为最常见的肉瘤类型。针对罕见病变进行大样本量研究有助于识别可能有助于正确诊断的人口统计学数据和组织病理学变异。
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