Brondino N, Rocchetti M, Fusar-Poli L, Codrons E, Correale L, Vandoni M, Barbui C, Politi P
Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy.
Laboratory of Adapted Motor Activity, Department of Public Health, Experimental Medicine & Forensic Science, University of Pavia, Pavia, Italy.
Acta Psychiatr Scand. 2017 Apr;135(4):285-295. doi: 10.1111/acps.12690. Epub 2017 Jan 22.
The aim of the present systematic review and meta-analysis was to evaluate the impact of physical exercise on cognitive symptoms in depressed adult patients.
Systematic literature search was performed in Web of Science™ and CINAHL from inception to August 2016. Two reviewers independently selected randomized trials evaluating the effect of exercise on cognitive functions in patients with a validated diagnosis of depression. Outcome measures included global cognition and different cognitive domains (speed of processing, attention/vigilance, working memory, verbal and visual memory, and reasoning).
Eight trials met inclusion criteria (637 patients). A fixed-effects model showed absence of beneficial effect on global cognition (Hedges' g = 0.07, 95% CI -0.08 to 0.24, I = 0%) as well as on specific cognitive domains. Sensitivity analyses did not show an impact of exercise in studies with shorter intervention duration compared to longer trials (between group heterogeneity Q = 3.564, df = 1, P = 0.059), single session per week compared to multiple sessions (Q = 2.691, df = 1, P = 0.101) and low exercise intensity compared with moderate/high intensity (Q = 2.952, df = 1, P = 0.086).
Our meta-analysis did not observe a substantial benefit of physical exercise on cognitive symptoms in depression.
本系统评价和荟萃分析旨在评估体育锻炼对成年抑郁症患者认知症状的影响。
在Web of Science™和CINAHL中进行系统文献检索，检索时间从数据库建立至2016年8月。两名研究者独立筛选随机试验，这些试验评估了运动对已确诊抑郁症患者认知功能的影响。结局指标包括整体认知及不同认知领域（处理速度、注意力/警觉性、工作记忆、言语和视觉记忆以及推理）。
八项试验符合纳入标准（637例患者）。固定效应模型显示，运动对整体认知（Hedges' g = 0.07，95%CI -0.08至0.24，I = 0%）以及特定认知领域均无有益影响。敏感性分析表明，与干预时间较长的试验相比，干预时间较短的研究中运动没有影响（组间异质性Q = 3.564，自由度df = 1，P = 0.059）；与每周多次运动相比，每周单次运动也没有影响（Q = 2.691，df = 1，P = 0.101）；与中/高强度运动相比，低强度运动同样没有影响（Q = 2.952，df = 1，P = 0.086）。
我们的荟萃分析未观察到体育锻炼对抑郁症认知症状有显著益处。
