Tang Ying, Cheung Belamy B, Atmadibrata Bernard, Marshall Glenn M, Dinger Marcel E, Liu Pei Y, Liu Tao
Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia; The Electron Microscopy Laboratory, Kunming Medical University, 1168 Chunrongxi Road, Chenggong District, Kunming, Yunnan Province, China.
Children's Cancer Institute Australia for Medical Research, Randwick, Sydney, NSW 2031, Australia.
Cancer Lett. 2017 Apr 10;391:12-19. doi: 10.1016/j.canlet.2017.01.010. Epub 2017 Jan 19.
With the advances in genomic analysis technologies, especially next-generation RNA sequencing, a large number of new transcripts have been discovered, leading to better understanding of long noncoding RNAs (lncRNAs). Recent investigations have provided firm evidence for the critical roles of lncRNAs in chromatin modification, gene transcription, RNA splicing, RNA transport and translation. In vitro and in vivo studies have also proven that aberrant lncRNA expression is essential for the initiation and progression of cancers. Due to their unique tissue- and cancer-specific expression profiles, aberrant expression of lncRNAs can be used as reliable prognostic markers for cancer diagnoses and treatment stratification, and lncRNAs are novel therapeutic targets with high therapeutic windows.
随着基因组分析技术的进步，尤其是新一代RNA测序技术的发展，大量新的转录本被发现，这有助于人们更好地了解长链非编码RNA（lncRNA）。最近的研究为lncRNA在染色质修饰、基因转录、RNA剪接、RNA转运和翻译中的关键作用提供了确凿证据。体外和体内研究也证明，lncRNA的异常表达对于癌症的发生和发展至关重要。由于lncRNA具有独特的组织和癌症特异性表达谱，其异常表达可作为癌症诊断和治疗分层的可靠预后标志物，并且lncRNA是具有高治疗窗口的新型治疗靶点。
