Camacho Cristel V, Choudhari Ramesh, Gadad Shrikanth S
Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Center of Emphasis in Cancer, Paul L. Foster School of Medicine, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, TX 79905, United States.
Steroids. 2018 May;133:93-95. doi: 10.1016/j.steroids.2017.12.012. Epub 2018 Jan 6.
Long noncoding RNAs (lncRNAs) are implicated in several biological processes, including but not limited to cardiovascular physiology, reproduction, differentiation, metabolism, DNA repair, and inflammation. Under normal physiological conditions, expression of lncRNAs is tissue-specific and tightly regulated. In contrast, prevalent cancer types exhibit aberrant expression of lncRNAs. In this context, lncRNAs can drive cancer cell characteristics by controlling gene expression programs related to tumor suppressive and oncogenic functions. Hence, they can be excellent biomarkers and targets for therapeutic intervention in cancers. Understanding the molecular mechanisms by which lncRNAs drive cancer progression will improve our understanding of the etiology of cancer and suggest new ways to treat this disease. This review will provide a perspective on the role of lncRNAs in cancer initiation and progression.
长链非编码RNA（lncRNAs）参与多种生物学过程，包括但不限于心血管生理、生殖、分化、代谢、DNA修复和炎症。在正常生理条件下，lncRNAs的表达具有组织特异性且受到严格调控。相反，常见癌症类型中lncRNAs呈现异常表达。在此背景下，lncRNAs可通过控制与肿瘤抑制和致癌功能相关的基因表达程序来驱动癌细胞特性。因此，它们可成为癌症治疗干预的优秀生物标志物和靶点。了解lncRNAs驱动癌症进展的分子机制将增进我们对癌症病因的理解，并为治疗该疾病提供新方法。本综述将阐述lncRNAs在癌症起始和进展中的作用。
