Sikandar Arbab, Zaneb Hafsa, Younus Muhammad, Masood Saima, Aslam Asim, Khattak Farina, Ashraf Saima, Yousaf Muhammad Shahbaz, Rehman Habib
Sub-campus, Jhang, University of Veterinary and Animal Sciences, Lahore 35200, Pakistan.
University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Asian-Australas J Anim Sci. 2017 May;30(5):690-699. doi: 10.5713/ajas.16.0824. Epub 2017 Jan 13.
This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine.
A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively. Six birds/group were killed on d-21 and d-35, and samples were collected.
Cell-mediated immune response at 48 h post-Phytohemagglutinin-P injection, and antibody titer against Newcastle disease vaccine and sheep red blood cells on d-35 was noted higher (p<0.05) in SB-1 compared to ZnB and control. Lower (p<0.05) feed conversion ratio (FCR) was attained by the supplemented groups. Thymus and spleen weighed more (p<0.05) in SB-1, and bursa registered more (p<0.05) weight in both SB groups compared to control. On d-21, areas of thymus medulla and spleen germinal centers were noted higher (p<0.05) in SB-1 group. The villus height and villus surface area increased (p<0.05) in duodenum and jejunum in both SB groups on d-21, and in SB-1 on d-35, respectively compared to ZnB and control. On d-21, number of goblet cells containing mucins of acidic nature increased (p<0.05) in all the segments of small intestines in SB-1 group compared to control, and on d-35 in ileum compared to other groups.
In conclusion, SB improved growth performance and immunity as well as modulated morphology of lymphoid organs and gut mucosa in broiler chickens.
本研究旨在探讨丁酸钠（SB）对肉鸡生长性能、免疫状态、器官重量以及淋巴器官和小肠微观结构的影响。
将120只1日龄的肉鸡雏鸡分为以下四个处理组：不添加任何物质的玉米 - 大豆基础日粮（BD）（对照组），或分别添加0.1 g/kg杆菌肽锌（ZnB）、0.5 g/kg SB（SB - 0.5）或1.0 g/kg SB（SB - 1）的相同基础日粮。在第21天和第35天每组宰杀6只鸡，并采集样本。
与ZnB组和对照组相比，SB - 1组在注射植物血凝素 - P后48小时的细胞介导免疫反应以及在第35天针对新城疫疫苗和绵羊红细胞的抗体效价更高（p<0.05）。添加组的饲料转化率（FCR）较低（p<0.05）。与对照组相比，SB - 1组的胸腺和脾脏重量更大（p<0.05），两个SB组的法氏囊重量均更高（p<0.05）。在第21天，SB - 1组的胸腺髓质和脾脏生发中心面积更高（p<0.05）。与ZnB组和对照组相比，两个SB组在第21天十二指肠和空肠的绒毛高度和绒毛表面积增加（p<0.05），SB - 1组在第35天分别增加。在第21天，与对照组相比，SB - 1组小肠各段含酸性粘蛋白的杯状细胞数量增加（p<0.05），在第35天回肠与其他组相比增加。
总之，SB改善了肉鸡的生长性能和免疫力，并调节了淋巴器官和肠道黏膜的形态。
