Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Department of Veterinary Medicine, University of Sassari, Sassari, Italy.
Open Vet J. 2024 Jan;14(1):324-334. doi: 10.5455/OVJ.2024.v14.i1.29. Epub 2024 Jan 31.
Butyric acid and its derivatives support the immune system, lessen inflammation, and lessen oxidative stress in broilers in addition to preserving gut homeostasis and epithelial integrity. Broiler performance has also been demonstrated to rise with the addition of nucleotides to the diet.
The purpose of the study was to ascertain the effects of butyric acid and nucleotides added to feed on the overall performance, immunity, oxidant/antioxidant enzyme levels, intestinal histology, and hepatic functions of broilers.
Four experimental groups of thirty chickens, each were used in the present study. The groups were assigned as a control group that received normal diet without additives, butyrate (B) group received the diet supplemented with butyric acid (250 g/ton feed), nucleotides (N) group received the diet supplemented with nucleotides (200 g/ton feed), and the fourth group received the diet supplemented with a combination of butyrate and nucleotide (BN) (250 g/ton B feed, and 200 g/ton N feed, respectively). Necrotic enteritis was produced in ten birds from each group to assess the immune-modulatory effect of these supplements, antioxidant status, intestinal histology, and liver functions were measured in all experimental groups.
The addition of butyric acid and nucleotides to feed enhanced body weight, growth performance, hepatic functions, and antioxidant capabilities. Histological sections of the gut from challenged or unchallenged (with necrotic enteritis) groups in the BN group showed considerable improvement, as shown by strong proliferation in intestinal crypts and villus enterocytes.
Nucleotides and butyric acid can be added to broiler feeding regimens to enhance growth and health.
丁酸及其衍生物除了维持肠道内环境稳定和上皮完整性外，还能支持免疫系统、减轻炎症和氧化应激。此外，在饲料中添加核苷酸还可以提高肉鸡的生产性能。
本研究旨在确定在饲料中添加丁酸和核苷酸对肉鸡整体性能、免疫、氧化/抗氧化酶水平、肠道组织学和肝功能的影响。
本研究使用了四组 30 只鸡的实验组。这些组被分为对照组（接受不含添加剂的正常饮食）、丁酸（B）组（添加 250 g/吨饲料的丁酸）、核苷酸（N）组（添加 200 g/吨饲料的核苷酸）和第四组（添加丁酸和核苷酸的组合（BN）（250 g/吨 B 饲料和 200 g/吨 N 饲料）。从每组中选择 10 只鸡产生坏死性肠炎，以评估这些补充剂的免疫调节作用，测量所有实验组的抗氧化状态、肠道组织学和肝功能。
在饲料中添加丁酸和核苷酸可以提高体重、生长性能、肝功能和抗氧化能力。BN 组中受挑战或未受挑战（发生坏死性肠炎）的肠道组织切片显示出明显的改善，肠隐窝和绒毛上皮细胞的强烈增殖表明肠道组织学有了很大的改善。
核苷酸和丁酸可以添加到肉鸡的饲养方案中，以提高生长和健康水平。
