Bio Moses, Rajaputra Pallavi, Lim Irene, Thapa Pritam, Tienabeso Bomaonye, Hurst Robert E, You Youngjae
Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
Chem Commun (Camb). 2017 Feb 7;53(11):1884-1887. doi: 10.1039/c6cc09994g. Epub 2017 Jan 23.
Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjugated in one molecule or mixed in nano-drug delivery systems. In this communication, we demonstrate a new strategy to activate prodrugs with photo-unclick chemistry in an intermolecular fashion using an SO-cleavable CA4 prodrug and a mitochondria-specific photosensitizer, protoporphyrin IX, formed from prodrug hexyl-5-aminolevulinate.
光解扣化学通过单线态氧（SO）可裂解的连接子介导可见光和近红外光控制的药物释放。由于SO在生物系统中的扩散距离有限，光敏剂和SO可裂解连接子已被共轭在一个分子中或混合在纳米药物递送系统中。在本通讯中，我们展示了一种新策略，即使用由前药己基-5-氨基乙酰丙酸形成的SO可裂解CA4前药和线粒体特异性光敏剂原卟啉IX，以分子间方式用光解扣化学激活前药。
