Xi'an Center for Disease Control and Prevention, Xi'an, China.
Xi'an Medical Emergency Center, Xi'an, China.
J Med Virol. 2017 Sep;89(9):1511-1519. doi: 10.1002/jmv.24769. Epub 2017 Jun 15.
To explore the epidemiological, phylogeographic, and migration characteristics of human rabies in Shaanxi province, China from 2009 to 2015. The collected data were described and the sequenced glycoprotein (G) and nucleoprotein (N) genes were implemented to estimate the evolutionary rates and phylogeographic patterns using BEAST v.1.8.2. A total of 269 rabies cases were reported and 70.26% of the cases were male and 61.71% were between the ages of 19-59. The majority of the cases were farmers (83.27%). The estimated evolutionary rate of the N genes was 2.4 × 10 substitutions/site/year and the G genes was 3.4 × 10 . The time of the most recent common ancestor (TMRCA) was estimated around 1990. We detected viral migration paths from Sichuan, Guizhou, and Hunan to Hanzhong prefecture of Shaanxi and then spreaded to Xi'an and other prefectures. The main population affected by rabies virus was male adult farmers. The evolution rate of rabies viruses in Shaanxi was similar with the prior results reported by others and the ancestor virus should be circulating in neighboring province Sichuan around 1990 and then transmitted to Shaanxi. Promptly standard wound treatment and timely post-exposure prophylaxis should be compulsory for the dog-bitten victims.
为了探索 2009 年至 2015 年期间陕西省人间狂犬病的流行病学、系统地理学和迁移特征。对收集的数据进行了描述，并对测序的糖蛋白（G）和核蛋白（N）基因进行了分析，使用 BEAST v.1.8.2 估计了进化率和系统地理学模式。共报告了 269 例狂犬病病例，其中 70.26%为男性，61.71%为 19-59 岁。大多数病例为农民（83.27%）。N 基因的估计进化率为 2.4×10 个取代/位点/年，G 基因的估计进化率为 3.4×10 个取代/位点/年。最近共同祖先（TMRCA）的时间估计在 1990 年左右。我们检测到了从四川、贵州和湖南到汉中的病毒迁移路径，然后传播到西安和其他地区。受狂犬病病毒影响的主要人群是成年男性农民。陕西省的狂犬病病毒进化率与其他人先前报告的结果相似，始祖病毒应该在 1990 年左右在邻近的四川省传播，并随后传播到陕西省。及时对犬伤受害者进行标准伤口处理和及时的暴露后预防是强制性的。
