灼口综合征患者唾液皮质醇和α-淀粉酶水平及心理特征的比较
Comparison of Salivary Cortisol and α-amylase Levels and Psychological Profiles in Patients with Burning Mouth Syndrome.
作者信息
Nosratzehi Tahereh, Salimi Saeedeh, Parvaee Azadeh
机构信息
Assistant Professor, Oral and Dental Disease Research Center, Department of Oral Medicine, Faculty of Dentistry, Zahedan University of Medical Science, Zahedan, Iran.
Associate Professor, Cellular and Molecular Research Center, Department of Clinical Biochemistry, Faculty of Medicine, Zahedan University of Medical Science, Zahedan, Iran.
出版信息
Spec Care Dentist. 2017 May;37(3):120-125. doi: 10.1111/scd.12214. Epub 2017 Jan 23.
PURPOSE
The aim of the study was to compare salivary cortisol and α-amylase levels and psychological profiles in patients with burning mouth syndrome (BMS) and healthy subjects.
METHODS AND MATERIALS
Spitting method was used to collect unstimulated salivary. Salivary cortisol and α-amylase levels were determined using ELISA and the Caraway starch-iodine technique. SLC-90 questionnaire was used to determine the psychological profiles.
RESULTS
The difference between mean of salivary cortisol levels in patients with BMS and in healthy subjects was not significant (4.50 ± 3.68 ng/mL vs. 3.69 ± 3.07 ng/mL, p = 0.377). The difference between mean of α-amylase levels in the BMS patients and healthy subjects was significant (351.68 ± 142.5 and 146.22 ± 130.4, p = 0.001). Note that, 83.4% and 18% of the patients in the case and control groups had psychological problems (p = 0.001).
CONCLUSION
The results showed higher salivary levels of cortisol and α-amylase in patients with BMS compared to healthy individuals. Psychological problem was prevalent in patients.
目的
本研究旨在比较灼口综合征（BMS）患者与健康受试者的唾液皮质醇和α-淀粉酶水平以及心理状况。
方法和材料
采用吐唾法收集非刺激性唾液。使用酶联免疫吸附测定法（ELISA）和香芹籽淀粉碘法测定唾液皮质醇和α-淀粉酶水平。使用症状自评量表90（SLC-90）问卷确定心理状况。
结果
BMS患者与健康受试者唾液皮质醇水平均值之间的差异不显著（4.50±3.68 ng/mL对3.69±3.07 ng/mL，p = 0.377）。BMS患者与健康受试者α-淀粉酶水平均值之间的差异显著（351.68±142.5和146.22±130.4，p = 0.001）。注意，病例组和对照组分别有83.4%和18%的患者存在心理问题（p = 0.001）。
结论
结果显示，与健康个体相比，BMS患者唾液中皮质醇和α-淀粉酶水平更高。心理问题在患者中普遍存在。
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