Zaruba A Iu, Kutsenko A I, Ma'lginov S V, Chuĭkin N A, Masenko V P
Klin Med (Mosk). 1989 Aug;67(8):89-92.
A course of hemosorption combined with chemotherapy resulted in much less frequent attacks of angina pectoris and in compensation of cardiac insufficiency in 27 coronary heart disease patients resistant to chemotherapy. There was an increase in the drugs efficacy. Sensitivity of the lymphocytes to chemotherapeutic agents administered rose as shown by rosette test due to specific unlocking of the receptors. The underlying mechanism of hemosorption-related compensation of cardiac insufficiency implies correction of secondary hyperaldosteronism and a decrease in the level of ADH leading to enhanced diuresis, natriuresis, inhibited kaliuresis and to normal values of blood electrolytes.
对于27例化疗耐药的冠心病患者，采用血液吸附联合化疗的疗程可使心绞痛发作频率显著降低，并使心功能不全得到代偿。药物疗效有所提高。通过玫瑰花结试验表明，由于受体的特异性解锁，淋巴细胞对所用化疗药物的敏感性增强。血液吸附相关的心功能不全代偿的潜在机制意味着继发性醛固酮增多症得到纠正，抗利尿激素水平降低，从而导致利尿、利钠增强，尿钾排泄受抑制，以及血液电解质值恢复正常。
