Maas Miriam, de Vries Ankje, van Roon Annika, Takumi Katsuhisa, van der Giessen Joke, Rockx Barry
Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM) , Bilthoven, the Netherlands .
Vector Borne Zoonotic Dis. 2017 Mar;17(3):200-205. doi: 10.1089/vbz.2016.1995. Epub 2017 Jan 23.
Tula virus (TULV) is a zoonotic hantavirus. Knowledge about TULV in the Netherlands is very scarce. Therefore in 2014, 49 common voles (Microtus arvalis) from a region in the south of the Netherlands, and in 2015, 241 common voles from regions in the north of the Netherlands were tested with the TULV quantitative RT-PCR. In the southern region, prevalence of TULV was 41% (20/49). In the northern regions, prevalence ranged from 12% (4/34) to 45% (17/38). Phylogenetic analysis of the obtained sequences showed that the regions fall within different clusters. Voles from the south were also tested on-site for the presence of hantavirus antibodies, but serology results were poorly associated with qRT-PCR results. These findings suggest that TULV may be more widespread than previously thought. No human TULV cases have been reported thus far in the Netherlands, but differentiation between infection by TULV or the closely related Puumala virus is not made in humans in the Netherlands, thus cases may be misdiagnosed.
图拉病毒（TULV）是一种人畜共患的汉坦病毒。在荷兰，关于图拉病毒的知识非常匮乏。因此，2014年对来自荷兰南部一个地区的49只普通田鼠（Microtus arvalis）进行了检测，2015年对来自荷兰北部地区的241只普通田鼠进行了图拉病毒定量逆转录聚合酶链反应检测。在南部地区，图拉病毒的流行率为41%（20/49）。在北部地区，流行率从12%（4/34）到45%（17/38）不等。对获得的序列进行系统发育分析表明，这些地区属于不同的聚类。还对来自南部的田鼠进行了现场汉坦病毒抗体检测，但血清学结果与定量逆转录聚合酶链反应结果的相关性较差。这些发现表明，图拉病毒可能比以前认为的更为广泛。荷兰迄今尚未报告人类感染图拉病毒的病例，但在荷兰，人类感染图拉病毒或密切相关的普马拉病毒的情况并未区分，因此病例可能会被误诊。
