Parks Elizabeth, Yki-Järvinen Hannele, Hawkins Meredith
J Clin Invest. 2017 Feb 1;127(2):454-456. doi: 10.1172/JCI92407. Epub 2017 Jan 23.
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin resistance, resulting in metabolic dysfunction. Dietary fat content probably influences both NAFLD and insulin resistance; however, the immediate effects of fat consumption have not been fully explored. In this issue of the JCI, Hernández et al. evaluated hepatic glucose and lipid metabolism in humans and mice following a single oral dose of saturated fat. This one bolus of fat resulted in a measurable increase in insulin resistance, hepatic triglycerides, and gluconeogenesis. In mice, the saturated fat bolus resulted in the induction of several NAFLD-associated genes. Together, the results of this study indicate that saturated fat intake has immediate effects on metabolic function.
非酒精性脂肪性肝病（NAFLD）的特征是肝脏中脂肪过度积累。在某些情况下，NAFLD还伴有胰岛素抵抗，导致代谢功能障碍。饮食中的脂肪含量可能会影响NAFLD和胰岛素抵抗；然而，脂肪摄入的即时影响尚未得到充分研究。在本期《临床研究杂志》（JCI）中，埃尔南德斯等人评估了单次口服饱和脂肪后人类和小鼠的肝脏葡萄糖和脂质代谢。这一剂脂肪导致胰岛素抵抗、肝脏甘油三酯和糖异生有可测量的增加。在小鼠中，饱和脂肪推注导致多个与NAFLD相关的基因被诱导。总之，这项研究的结果表明饱和脂肪摄入对代谢功能有即时影响。
