Serra Agostino, Maiolino Luigi, Cocuzza Salvatore, Di Luca Milena, Campione Gianluca, Licciardello Luisa, Di Mauro Paola
ENT University of Catania.Azienda Ospedaliera Universitaria “Policlinico â€" Vittorio Emanueleâ€, University of Catania â€" Via Santa Sofia n. 78 â€" 95123 Catania (Italy) â€" Telephone number: (39) 095/3781093 â€" Fax number: (39) 095/7335738..
Acta Biomed. 2016 Jan 16;87(3):253-258.
In OSAHS, the hypoxia and reoxygenation cicles, maintain a state of oxidative stress, which seems to cause a change in the oxidative balance. Our aim is to compare the markers of oxidative stress with audiological findings and OSAHS severity, in OSAHS patients untreated and also treated ones, with cysteine and superoxide dismutase.
65 patients (42 Men, 23 Women) with 30-65 years age range have been enrolled, with a mean age of 52.6 ± 13.3 years with moderate OSAHS. We have analyzed plasma and lymphocyte markers of oxidative stress (glutathione, thioredoxin and heat shock protein) and they were underwent tonal audiometry. Patients were divided in two groups: Group A (32 patients) included patients treated for 8 weeks with cysteine and superoxide dismutase; Group B (33 patients) included patients untreated.
The research showed a significant increase in reduced glutathione levels (p<0.05) in OSAHS patients treated; conversely, it showed a decrease of oxidized glutathione level (p<0.05) in treated patients than OSAHS untreated ones. The thioredoxin values, in untreated OSAHS patients, appear to be reduced than in OSAHS patients treated (p<0.05), and that the heat shock protein values were more elevated in untreated OSAHS patients (p<0.05). Finally, it was found that a correlation exists between the severity of OSAHS and auditory dysfunction.
The study of the oxidative stress markers has produced results which lead to support the idea that, in a personalized therapy context, the use of antioxidant therapy can cooperate effectively the first choice treatment.
在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）中，缺氧和复氧循环维持着氧化应激状态，这似乎会导致氧化平衡的改变。我们的目的是比较未经治疗和经治疗的OSAHS患者氧化应激标志物与听力学检查结果及OSAHS严重程度，并研究半胱氨酸和超氧化物歧化酶的作用。
纳入65例年龄在30 - 65岁之间的患者（42例男性，23例女性），平均年龄为52.6±13.3岁，均为中度OSAHS。我们分析了血浆和淋巴细胞中的氧化应激标志物（谷胱甘肽、硫氧还蛋白和热休克蛋白），并对他们进行了纯音听力测试。患者分为两组：A组（32例患者）包括接受半胱氨酸和超氧化物歧化酶治疗8周的患者；B组（33例患者）包括未接受治疗的患者。
研究表明，接受治疗的OSAHS患者还原型谷胱甘肽水平显著升高（p<0.05）；相反，与未经治疗的OSAHS患者相比，接受治疗的患者氧化型谷胱甘肽水平降低（p<0.05）。未经治疗的OSAHS患者硫氧还蛋白值似乎低于接受治疗的OSAHS患者（p<0.05），且未经治疗的OSAHS患者热休克蛋白值更高（p<0.05）。最后，发现OSAHS的严重程度与听觉功能障碍之间存在相关性。
氧化应激标志物的研究结果支持了这样一种观点：在个性化治疗背景下，抗氧化治疗可有效辅助首选治疗。
