Broderson J R
Office of Scientific Services, Center for Disease Control, Atlanta, GA 30333.
Lab Anim Sci. 1989 Sep;39(5):400-5.
A retrospective evaluation was made of lesions observed after the use of Freund's adjuvant formulations in rabbits and monkeys. Inflammation was consistently present at the sites of inoculation. Complications frequently included focal necrosis and ulceration of the skin. Other lesions included fistulous tracts, self-induced trauma, muscle atrophy, hypersensitivity pneumonitis, and embolic pneumonia. Lesions were most severe with formulations containing larger quantities of mycobacteria or with larger volumes of adjuvant injected per site.
对在兔子和猴子身上使用弗氏佐剂制剂后观察到的病变进行了回顾性评估。接种部位始终存在炎症。并发症经常包括皮肤局灶性坏死和溃疡。其他病变包括瘘管、自伤、肌肉萎缩、过敏性肺炎和栓塞性肺炎。含有较多分枝杆菌的制剂或每个部位注射较大体积佐剂时，病变最为严重。
