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Variants in ANGPTL4 and the Risk of Coronary Artery Disease.

作者信息

Stitziel Nathan O

机构信息

Washington University School of Medicine, St. Louis, MO

出版信息

N Engl J Med. 2016 Dec 8;375(23):2306. doi: 10.1056/NEJMc1607380.

DOI:10.1056/NEJMc1607380
PMID:28112900
Abstract
摘要

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Variants in ANGPTL4 and the Risk of Coronary Artery Disease.血管生成素样蛋白4(ANGPTL4)的变异与冠状动脉疾病风险
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Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.血管生成素样蛋白4的失活变异与冠状动脉疾病风险
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Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients.血管生成素样蛋白4可显著预测冠心病患者未来发生心血管事件的风险。
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Variants in ANGPTL4 and the Risk of Coronary Artery Disease.血管生成素样蛋白4(ANGPTL4)的变异与冠状动脉疾病风险
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Variants in ANGPTL4 and the Risk of Coronary Artery Disease.
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Variants within HNF1α and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study.捷克人群中HNF1α和ANGPTL4基因变异与急性冠状动脉综合征。GENDEMIP研究。
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Angiopoietin-like protein 4 serum levels and gene polymorphisms are associated with large artery atherosclerotic stroke.血管生成素样蛋白4血清水平及基因多态性与大动脉粥样硬化性卒中相关。
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Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development.血管生成素样蛋白 4 过表达可预防动脉粥样硬化发展。
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Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton.细胞外基质结合的血管生成素样4抑制内皮细胞黏附、迁移和芽生,并改变肌动蛋白细胞骨架。
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Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease.内皮细胞血管生成素样蛋白4缺失引起的代谢重编程可预防糖尿病肾病。
bioRxiv. 2025 May 12:2025.05.08.652142. doi: 10.1101/2025.05.08.652142.
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Angiopoietin-like Proteins and Lipoprotein Lipase: The Waltz Partners That Govern Triglyceride-Rich Lipoprotein Metabolism? Impact on Atherogenesis, Dietary Interventions, and Emerging Therapies.血管生成素样蛋白与脂蛋白脂肪酶:调控富含甘油三酯脂蛋白代谢的华尔兹舞伴?对动脉粥样硬化形成、饮食干预及新兴疗法的影响
J Clin Med. 2024 Sep 4;13(17):5229. doi: 10.3390/jcm13175229.
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ANGPTL4-the Link Binding Lipid Metabolism and Inflammation.
血管生成素样蛋白4——脂质代谢与炎症的联系纽带
Curr Med Chem. 2025;32(15):2931-2949. doi: 10.2174/0109298673320024240829070906.
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Current Developments of Clinical Sequencing and the Clinical Utility of Polygenic Risk Scores in Inflammatory Diseases.临床测序的最新进展和多基因风险评分在炎症性疾病中的临床应用。
Front Immunol. 2021 Jan 29;11:577677. doi: 10.3389/fimmu.2020.577677. eCollection 2020.
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Front Cell Dev Biol. 2019 Apr 5;7:48. doi: 10.3389/fcell.2019.00048. eCollection 2019.
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ANGPTL4 gene E40K variation protects against obesity-associated dyslipidemia in participants with obesity.血管生成素样蛋白4(ANGPTL4)基因E40K变异可预防肥胖参与者的肥胖相关血脂异常。
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variants and their haplotypes are associated with serum lipid levels, the risk of coronary artery disease and ischemic stroke and atorvastatin cholesterol-lowering responses.变异体及其单倍型与血清脂质水平、冠状动脉疾病和缺血性中风风险以及阿托伐他汀降低胆固醇的反应相关。
Nutr Metab (Lond). 2018 Oct 5;15:70. doi: 10.1186/s12986-018-0308-5. eCollection 2018.
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Diabetes Care. 2018 Nov;41(11):2404-2413. doi: 10.2337/dc18-0709. Epub 2018 Sep 27.
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Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.使用微阵列和下一代测序技术对糖尿病阿基塔小鼠进行心脏转录组分析。
PLoS One. 2017 Aug 24;12(8):e0182828. doi: 10.1371/journal.pone.0182828. eCollection 2017.