Zou Jian, Mo Xiaolian, Shi Zhongmin, Li Tanzhu, Xue Jianfeng, Mei Guohua, Li Xiaolin
Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
The People's Hospital of Shigatse City, Shigatse, Tibet 857000, China.
Biomed Res Int. 2016;2016:9364170. doi: 10.1155/2016/9364170. Epub 2016 Dec 28.
Acute Achilles tendon rupture is one of the most common tendon injuries in adults. We hypothesized that Platelet-Rich Plasma (PRP) can be used as biological augmentation for surgical treatment of acute Achilles tendon rupture. Our study is a prospective randomized controlled trial. Patients with acute Achilles tendon rupture undergoing surgical repair were randomly assigned into either control group or PRP group. End-to-end modified Krackow suture was performed in both groups. In the PRP group, PRP was injected into the paratenon sheath and around the ruptured tissue after the tendon was repaired. Postoperatively we evaluated isokinetic muscle strength at 3, 6, 12, and 24 months. In addition, ankle ROM, calf circumference, Leppilahti score, and the SF-36 score were evaluated at 6, 12, and 24 months after operation. At 3 months, the PRP group had better isokinetic muscle. The PRP group also achieved higher SF-36 and Leppilahti scores at 6 and 12 months. At 24 months, the PRP group had an improved ankle range of motion compared to the control group. Our study results suggest that PRP can serve as a biological augmentation to acute Achilles tendon rupture repair and improves both short and midterm functional outcomes.
急性跟腱断裂是成人中最常见的肌腱损伤之一。我们假设富血小板血浆（PRP）可作为急性跟腱断裂手术治疗的生物增强剂。我们的研究是一项前瞻性随机对照试验。接受手术修复的急性跟腱断裂患者被随机分为对照组或PRP组。两组均采用改良Krackow端端缝合。在PRP组中，肌腱修复后将PRP注入腱周组织和断裂组织周围。术后我们在3、6、12和24个月评估等速肌力。此外，在术后6、12和24个月评估踝关节活动度、小腿周长、Leppilahti评分和SF-36评分。在3个月时，PRP组的等速肌力更好。PRP组在6个月和12个月时的SF-36评分和Leppilahti评分也更高。在24个月时，与对照组相比，PRP组的踝关节活动度有所改善。我们的研究结果表明，PRP可作为急性跟腱断裂修复的生物增强剂，并改善短期和中期功能结局。
