Jia Yane, Yang Jiayun, Wang Zhengxiang, Du Yingying, Cui Jie, Wang Liang, Guo Fengfeng, Yang Maijuan, Han Shufang, Zhu Qiyun
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, 1 Xujiaping, Lanzhou, 730046, China.
Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Arch Virol. 2017 May;162(5):1349-1353. doi: 10.1007/s00705-017-3234-3. Epub 2017 Jan 23.
In this study, we analyzed the genome of a H10N5 influenza virus from wild birds. This virus was identified as a novel reassortant virus with internal genes from multiple subtypes and of distinct origins. After sequential passage in mice, mouse-adapted viruses bearing mutations PB2-E627K and HA-G218E were generated. These viruses caused dramatic body weight loss and death, and also replicated in mouse brain, suggesting that the pathogenicity of low pathogenic H10N5 in chickens can be enhanced after passage in mammals. Our data imply that H10N5 viruses might be a potential risk to human health therefore it is important to undertake continued surveillance and biosecurity evaluation of these viruses.
在本研究中，我们分析了一种来自野生鸟类的H10N5流感病毒的基因组。该病毒被鉴定为一种新型重配病毒，其内部基因来自多个不同亚型且起源各异。在小鼠中连续传代后，产生了携带PB2-E627K和HA-G218E突变的适应小鼠的病毒。这些病毒导致显著的体重减轻和死亡，并且还在小鼠脑中复制，这表明低致病性H10N5在鸡中的致病性在哺乳动物传代后可能会增强。我们的数据表明，H10N5病毒可能对人类健康构成潜在风险，因此对这些病毒进行持续监测和生物安全评估非常重要。
