Schlechter烟堇草提取物和普罗托品的体内抗惊厥活性
In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb.
作者信息
Prokopenko Yuliya, Tsyvunin Vadim, Shtrygol' Sergey, Georgiyants Victoriya
机构信息
Department of Drugs Quality, Standardization and Certification, Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine.
Department of Pharmacology, National University of Pharmacy, Pushkinska 53, Kharkiv 61002, Ukraine.
出版信息
Sci Pharm. 2015 Dec 6;84(3):547-554. doi: 10.3390/scipharm84030547.
The present study aimed to investigate the role of several biologically active compounds from Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysaccharide-protein complex were isolated from the herb and studied along with dry extract in mice with pentylenetetrazole-induced seizures. According to empirical results, the expressed anticonvulsant effect of dry extract depends on the synergism of biologically active compounds in herbal medicine, although some individual substances (mostly protopine and the protein-polysaccharide fraction) have shown moderate anti-seizure activity.
本研究旨在探讨来自Soy.-Will.的几种生物活性化合物在抗惊厥模型中的作用。从该草药中分离出黄酮类成分、生物碱成分、单一生物碱原阿片碱以及多糖-蛋白质复合物，并与干提取物一起在戊四氮诱导癫痫发作的小鼠中进行研究。根据实验结果，干提取物所表现出的抗惊厥作用取决于草药中生物活性化合物的协同作用，尽管一些单一物质（主要是原阿片碱和蛋白质-多糖成分）已显示出适度的抗癫痫活性。
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