Păltinean Ramona, Mocan Andrei, Vlase Laurian, Gheldiu Ana-Maria, Crișan Gianina, Ielciu Irina, Voștinaru Oliviu, Crișan Ovidiu
Department of Pharmaceutical Botany, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania.
Molecules. 2017 Apr 15;22(4):639. doi: 10.3390/molecules22040639.
Romanian traditional medicine describes the use of aerial parts of species to treat hepatobiliary diseases as well as diuretic agents. The present study aims to investigate the chemical composition, antioxidant properties, and diuretic effects of several species. LC/MS analysis revealed that species contain phenolic acids and high amounts of flavonoids with rutin and isoquercitrin as main compounds. Concerning antioxidant capacity, the most significant results were obtained for and . Both species showed a good correlation between the antioxidant capacity and a high amount of flavonoids. Furthermore, the extracts of and produced a strong increase in urinary volumetric excretion of saline-loaded rats, 24 h after the oral administration of a single dose of 250 mg/kg bw. Moreover, both extracts of and increased the urinary excretion of Na⁺ and K⁺. Results from the present study offer a new perspective concerning the chemical composition and bioactivities of traditionally used fumitory species.
罗马尼亚传统医学描述了使用该物种的地上部分来治疗肝胆疾病以及作为利尿剂。本研究旨在调查几种该物种的化学成分、抗氧化特性和利尿作用。液相色谱/质谱分析表明，该物种含有酚酸和大量以芦丁和异槲皮苷为主要化合物的黄酮类化合物。关于抗氧化能力，该物种和该物种获得了最显著的结果。这两个物种在抗氧化能力和大量黄酮类化合物之间都显示出良好的相关性。此外，该物种和该物种的提取物在口服单剂量250mg/kg体重24小时后，使盐水负荷大鼠的尿体积排泄量大幅增加。此外，该物种和该物种的两种提取物都增加了Na⁺和K⁺的尿排泄量。本研究结果为传统使用的烟堇属物种的化学成分和生物活性提供了新的视角。
